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@ARTICLE{Csiszar:10587,
      author       = {Csiszar, A. and Hersch, N. and Dieluweit, S. and Biehl, R.
                      and Merkel, R. and Hoffmann, B.},
      title        = {{N}ovel {F}usogenic {L}iposomes for {F}luorescent {C}ell
                      labeling and {M}embrane {M}odification},
      journal      = {Bioconjugate chemistry},
      volume       = {21},
      issn         = {1043-1802},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-10587},
      pages        = {537 - 543},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Efficient delivery of biomolecules into membranes of living
                      cells as well as cell surface modifications are major
                      biotechnological challenges. Here, novel liposome systems
                      based on neutral and cationic lipids in combination with
                      lipids modified by aromatic groups are introduced for such
                      applications. The fusion efficiency of these liposome
                      systems was tested on single cells in culture like HEK293,
                      myofibroblasts, cortical neurons, human macrophages, smooth
                      muscle cells, and even on tissue. Fusogenic liposomes
                      enabled highly efficient incorporation of molecules into
                      mammalian cell membranes within 1 to 30 min at fully
                      unchanged cell growth conditions and did not affect cell
                      behavior. We hypothesize that membrane fusions were induced
                      in all cases by the interaction of the positively charged
                      lipids and the delocalized electron system of the aromatic
                      group generating local dipoles and membrane instabilities.
                      Selected applications ranging from basic research to
                      biotechnology are envisaged here.},
      keywords     = {J (WoSType)},
      cin          = {IBN-4 / IFF-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB802 / I:(DE-Juel1)VDB785},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung / Erneuerbare Energien},
      pid          = {G:(DE-Juel1)FUEK505 / G:(DE-Juel1)FUEK401},
      shelfmark    = {Biochemical Research Methods / Biochemistry $\&$ Molecular
                      Biology / Chemistry, Multidisciplinary / Chemistry, Organic},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20184308},
      UT           = {WOS:000275711600016},
      doi          = {10.1021/bc900470y},
      url          = {https://juser.fz-juelich.de/record/10587},
}