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000010744 0247_ $$2DOI$$a10.1016/j.neuroimage.2010.05.080
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000010744 084__ $$2WoS$$aNeurosciences
000010744 084__ $$2WoS$$aNeuroimaging
000010744 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000010744 1001_ $$0P:(DE-HGF)0$$aSantos, N.$$b0
000010744 245__ $$aAnimated brain: A functional neuroimaging study on animacy experience
000010744 260__ $$aOrlando, Fla.$$bAcademic Press$$c2010
000010744 300__ $$a291 - 302
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000010744 440_0 $$04545$$aNeuroImage$$v53$$x1053-8119$$y1
000010744 500__ $$aWe would like to thank Barbara Elghahwagi and Cordula Kemper for their assistance with the fMRI scanning; Carolin Aumann for help with the subject's recruitment; and Bettina Bewernick, Alexandra Georgescu, Astrid Gawronski, Hanna Kockler, Leonhard Schilbach, and Ralf Tepest for their valuable comments on the study. This work was supported by the German Volkswagen-Stiftung (Kai Vogeley) and the Portuguese scientific foundation Fundacao para a Ciencia e Tecnologia (FCT), the latest in the form of a fellowship to Natacha Santos.
000010744 520__ $$aPrevious research used animated geometric figures to investigate social cognitive processes involved in ascribing mental states to others (e.g. mentalizing). The relationship between animacy perception and brain areas commonly involved in social cognition, as well as the influence of particular motion patterns on animacy experience, however, remains to be further elucidated. We used a recently introduced paradigm for the systematic variation of motion properties, and employed functional magnetic resonance imaging to identify the neural mechanisms underlying animacy experience. Based on individual ratings of increased animacy experience the following brain regions of the "social neural network" (SNN), known to be involved in social cognitive processes, were recruited: insula, superior temporal gyrus, fusiform gyrus, parahippocampal gyrus and the ventromedial prefrontal cortex bilaterally. Decreased animacy experience was associated with increased neural activity in the inferior parietal and inferior frontal gyrus, key constituents of the human "mirror neuron system" (hMNS). These findings were corroborated when analyses were based on movement patterns alone, irrespective of subjective experience. Additionally to the areas found for increased animacy experience, an increase in interactive movements elicited activity in the amygdala and the temporal pole. In conclusion, the results suggest that the hMNS is recruited during a low-level stage of animacy judgment representing a basic disposition to detect the salience of movements, whereas the SNN appears to be a high-level processing component serving evaluation in social and mental inference.
000010744 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000010744 588__ $$aDataset connected to Web of Science, Pubmed
000010744 65320 $$2Author$$aAnimacy
000010744 65320 $$2Author$$aInsula
000010744 65320 $$2Author$$aMentalizing
000010744 65320 $$2Author$$aMirror neuron system (MNS)
000010744 65320 $$2Author$$aSocial neural network (SNN)
000010744 65320 $$2Author$$aSuperior temporal sulcus
000010744 65320 $$2Author$$aOrbitofrontal cortex
000010744 65320 $$2Author$$aVentromedial prefrontal cortex
000010744 650_2 $$2MeSH$$aAdult
000010744 650_2 $$2MeSH$$aBrain: physiology
000010744 650_2 $$2MeSH$$aCognition: physiology
000010744 650_2 $$2MeSH$$aCues
000010744 650_2 $$2MeSH$$aHumans
000010744 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000010744 650_2 $$2MeSH$$aMale
000010744 650_2 $$2MeSH$$aMotion Perception: physiology
000010744 650_2 $$2MeSH$$aPhotic Stimulation: methods
000010744 650_7 $$2WoSType$$aJ
000010744 7001_ $$0P:(DE-Juel1)144165$$aKuzmanovic, B.$$b1
000010744 7001_ $$0P:(DE-HGF)0$$aDavid, N.$$b2
000010744 7001_ $$0P:(DE-HGF)0$$aRotarska-Jagiela, A.$$b3
000010744 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b4$$uFZJ
000010744 7001_ $$0P:(DE-Juel1)131794$$aShah, J. N.$$b5$$uFZJ
000010744 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b6$$uFZJ
000010744 7001_ $$0P:(DE-HGF)0$$aBente, G.$$b7
000010744 7001_ $$0P:(DE-HGF)0$$aVogeley, K:$$b8
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