000010795 001__ 10795
000010795 005__ 20210129210526.0
000010795 0247_ $$2DOI$$a10.1016/j.neurobiologaing.2009.05.004
000010795 0247_ $$2WOS$$aWOS:000289957000012
000010795 037__ $$aPreJuSER-10795
000010795 041__ $$aeng
000010795 082__ $$a610
000010795 084__ $$2WoS$$aGeriatrics & Gerontology
000010795 084__ $$2WoS$$aNeurosciences
000010795 1001_ $$0P:(DE-HGF)0$$aGaribotto, V.$$b0
000010795 245__ $$aSubcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration
000010795 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2011
000010795 300__ $$a875 - 884
000010795 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000010795 3367_ $$2DataCite$$aOutput Types/Journal article
000010795 3367_ $$00$$2EndNote$$aJournal Article
000010795 3367_ $$2BibTeX$$aARTICLE
000010795 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000010795 3367_ $$2DRIVER$$aarticle
000010795 440_0 $$017821$$aNeurobiology of Aging$$v32$$x0197-4580$$y5
000010795 500__ $$aThis work was financially supported by EULO (Ente Universitario Lombardia Orientale), and DIMI (Diagnostic Molecular Imaging). Sixth European Program, Project No: LSHB-CT-2005-512146.
000010795 520__ $$aThough neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured caudate, putamen, thalamus, and amygdala GM volume using probabilistic a-priori regions of interest (ROIs) in 53 early FTLD patients (38 behavioral variant FTD [bvFTD], 9 Semantic Dementia [SD], 6 Progressive Non-Fluent Aphasia [PNFA]), and 25 age-matched healthy controls (HC). ANOVA showed significant (P<0.001) main effect of diagnosis, and significant interactions for diagnosis and region, and diagnosis and hemisphere. Post-hoc comparisons with HC showed bilateral GM atrophy in the caudate, putamen and thalamus, in bvFTD; a left-confined GM reduction in the amygdala in SD; and bilateral GM atrophy in the caudate and thalamus, and left-sided GM reduction in the putamen and amygdala in PNFA. Correlation analyses suggested an association between GM volumes and language, psychomotor speed and behavioral disturbances. This study showed a widespread involvement of subcortical and deep cortical GM in early FTLD with patterns specific for clinical entity. (C) 2009 Elsevier Inc. All rights reserved.
000010795 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000010795 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000010795 588__ $$aDataset connected to Web of Science
000010795 65320 $$2Author$$aFrontotemporal Lobar Degeneration
000010795 65320 $$2Author$$aBasal ganglia
000010795 65320 $$2Author$$aProbabilistic atlases
000010795 65320 $$2Author$$aBehavioral variant Frontotemporal Dementia
000010795 65320 $$2Author$$aSemantic Dementia
000010795 65320 $$2Author$$aProgressive Non-Fluent Aphasia
000010795 650_7 $$2WoSType$$aJ
000010795 7001_ $$0P:(DE-HGF)0$$aBorroni, B.$$b1
000010795 7001_ $$0P:(DE-HGF)0$$aAgosti, C.$$b2
000010795 7001_ $$0P:(DE-HGF)0$$aPremi, E.$$b3
000010795 7001_ $$0P:(DE-HGF)0$$aAlberici, A.$$b4
000010795 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b5$$uFZJ
000010795 7001_ $$0P:(DE-HGF)0$$aBrambati, S.M.$$b6
000010795 7001_ $$0P:(DE-HGF)0$$aBellelli, G.$$b7
000010795 7001_ $$0P:(DE-HGF)0$$aGasparotti, R.$$b8
000010795 7001_ $$0P:(DE-HGF)0$$aPerani, D.$$b9
000010795 7001_ $$0P:(DE-HGF)0$$aPadovani, A.$$b10
000010795 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiologaing.2009.05.004$$gVol. 32, p. 875 - 884$$p875 - 884$$q32<875 - 884$$tNeurobiology of aging$$v32$$x0197-4580$$y2011
000010795 8567_ $$uhttp://dx.doi.org/10.1016/j.neurobiologaing.2009.05.004
000010795 909CO $$ooai:juser.fz-juelich.de:10795$$pVDB
000010795 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000010795 9141_ $$y2011
000010795 9132_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000010795 9131_ $$0G:(DE-HGF)POF2-89571$$1G:(DE-HGF)POF3-890$$2G:(DE-HGF)POF3-800$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vConnectivity and Activity$$x1
000010795 9201_ $$0I:(DE-Juel1)INM-2-20090406$$gINM$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
000010795 970__ $$aVDB:(DE-Juel1)121366
000010795 980__ $$aVDB
000010795 980__ $$aConvertedRecord
000010795 980__ $$ajournal
000010795 980__ $$aI:(DE-Juel1)INM-2-20090406
000010795 980__ $$aUNRESTRICTED