TY  - JOUR
AU  - Garibotto, V.
AU  - Borroni, B.
AU  - Agosti, C.
AU  - Premi, E.
AU  - Alberici, A.
AU  - Eickhoff, S. B.
AU  - Brambati, S.M.
AU  - Bellelli, G.
AU  - Gasparotti, R.
AU  - Perani, D.
AU  - Padovani, A.
TI  - Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration
JO  - Neurobiology of aging
VL  - 32
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-10795
SP  - 875 - 884
PY  - 2011
N1  - This work was financially supported by EULO (Ente Universitario Lombardia Orientale), and DIMI (Diagnostic Molecular Imaging). Sixth European Program, Project No: LSHB-CT-2005-512146.
AB  - Though neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured caudate, putamen, thalamus, and amygdala GM volume using probabilistic a-priori regions of interest (ROIs) in 53 early FTLD patients (38 behavioral variant FTD [bvFTD], 9 Semantic Dementia [SD], 6 Progressive Non-Fluent Aphasia [PNFA]), and 25 age-matched healthy controls (HC). ANOVA showed significant (P<0.001) main effect of diagnosis, and significant interactions for diagnosis and region, and diagnosis and hemisphere. Post-hoc comparisons with HC showed bilateral GM atrophy in the caudate, putamen and thalamus, in bvFTD; a left-confined GM reduction in the amygdala in SD; and bilateral GM atrophy in the caudate and thalamus, and left-sided GM reduction in the putamen and amygdala in PNFA. Correlation analyses suggested an association between GM volumes and language, psychomotor speed and behavioral disturbances. This study showed a widespread involvement of subcortical and deep cortical GM in early FTLD with patterns specific for clinical entity. (C) 2009 Elsevier Inc. All rights reserved.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000289957000012
DO  - DOI:10.1016/j.neurobiologaing.2009.05.004
UR  - https://juser.fz-juelich.de/record/10795
ER  -