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000010798 0247_ $$2DOI$$a10.1038/ki.2010.253
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000010798 041__ $$aeng
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000010798 084__ $$2WoS$$aUrology & Nephrology
000010798 1001_ $$0P:(DE-Juel1)VDB7479$$aLux, S.$$b0$$uFZJ
000010798 245__ $$aDifferential activation of memory-relevant brain regions during a dialysis cycle
000010798 260__ $$a[S.l.]$$bWiley-Blackwell$$c2010
000010798 300__ $$a794 - 802
000010798 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010798 440_0 $$022941$$aKidney International$$v78$$x0098-6577
000010798 500__ $$aThe excellent support and cooperation of the following colleagues in dialysis centers is gratefully acknowledged: Stefan Heidenreich, Roland Bohm, Maria Ritzerfeld, KfH Aachen; Peter Weidemann, Athina Vassiliadou, Aachen; Sebastian Drube, Bernd Wolbert, Katrin Muller, Duren; Stefan Holzmann, Erkelenz; Waltraut Hofmann, Achim Fritz, KfH Linnich. In addition, the support of the following members of the MRI group of the Institute of Neurosciences and Medicine of the Research Center Julich is gratefully acknowledged: Veronika Ermer, Heiko Neeb, and Cordula Kemper.
000010798 520__ $$aCognitive impairment is a common and largely undiagnosed finding in a significant number of dialysis patients. These alterations may result from concomitant cerebrovascular disease, hemodynamic instability, the uremic milieu, or changes induced by the dialysis process. In order to gain further insight into this, we recruited 12 stable chronic hemodialysis patients (without clinical neurological disease) and an age- and gender-matched cohort of 12 control individuals (without renal or neurological problems) in a prospective, single-center study. In order to disentangle the influence of dialysis itself on memory function, each dialysis patient was tested twice: once immediately before dialysis following a long weekend (t1) and again the day after this dialysis (t2). The control individuals were tested in the same time frame. Neuropsychological testing found that the control individuals performed significantly better in verbal learning, motor speed, task switching, verbal comprehension, word fluency, spatial visualization, spatial perception, and reasoning; all independent of the time point. Functional magnetic resonance imaging of the whole brain in seven hemodialysis patients found significantly more bilateral activation of the hippocampus during the verbal working memory task at t2 relative to t1 compared with their seven matched control counterparts. Thus, our study found differential and task-specific activation of memory-relevant brain areas during a dialysis cycle.
000010798 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000010798 536__ $$0G:(DE-HGF)POF2-89572$$a89572 - (Dys-)function and Plasticity (POF2-89572)$$cPOF2-89572$$fPOF II T$$x1
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000010798 65320 $$2Author$$adementia
000010798 65320 $$2Author$$adialysis volume
000010798 65320 $$2Author$$aend-stage renal disease
000010798 65320 $$2Author$$auremia
000010798 650_2 $$2MeSH$$aAdult
000010798 650_2 $$2MeSH$$aBrain Mapping
000010798 650_2 $$2MeSH$$aCase-Control Studies
000010798 650_2 $$2MeSH$$aCognition Disorders: etiology
000010798 650_2 $$2MeSH$$aFemale
000010798 650_2 $$2MeSH$$aHippocampus: physiopathology
000010798 650_2 $$2MeSH$$aHumans
000010798 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000010798 650_2 $$2MeSH$$aMale
000010798 650_2 $$2MeSH$$aMemory: physiology
000010798 650_2 $$2MeSH$$aMiddle Aged
000010798 650_2 $$2MeSH$$aNeuropsychological Tests
000010798 650_2 $$2MeSH$$aProspective Studies
000010798 650_2 $$2MeSH$$aRenal Dialysis: adverse effects
000010798 650_2 $$2MeSH$$aVerbal Learning
000010798 650_2 $$2MeSH$$aYoung Adult
000010798 650_7 $$2WoSType$$aJ
000010798 7001_ $$0P:(DE-Juel1)VDB1072$$aMirzazade, S.$$b1$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)144165$$aKuzmanovic, B.$$b2$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)VDB90105$$aPlewan, T.$$b3$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b4$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)131794$$aShah, J. N.$$b5$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)VDB93705$$aFloege, J.$$b6$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b7$$uFZJ
000010798 7001_ $$0P:(DE-Juel1)VDB92610$$aEitner, F.$$b8$$uFZJ
000010798 773__ $$0PERI:(DE-600)2027941-3$$a10.1038/ki.2010.253$$gVol. 78, p. 794 - 802$$p794 - 802$$q78<794 - 802$$tKidney international / Supplements$$v78$$x0098-6577$$y2010
000010798 8567_ $$uhttp://dx.doi.org/10.1038/ki.2010.253
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