% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Lux:10798,
      author       = {Lux, S. and Mirzazade, S. and Kuzmanovic, B. and Plewan, T.
                      and Eickhoff, S. B. and Shah, J. N. and Floege, J. and Fink,
                      G. R. and Eitner, F.},
      title        = {{D}ifferential activation of memory-relevant brain regions
                      during a dialysis cycle},
      journal      = {Kidney international / Supplements},
      volume       = {78},
      issn         = {0098-6577},
      address      = {[S.l.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {PreJuSER-10798},
      pages        = {794 - 802},
      year         = {2010},
      note         = {The excellent support and cooperation of the following
                      colleagues in dialysis centers is gratefully acknowledged:
                      Stefan Heidenreich, Roland Bohm, Maria Ritzerfeld, KfH
                      Aachen; Peter Weidemann, Athina Vassiliadou, Aachen;
                      Sebastian Drube, Bernd Wolbert, Katrin Muller, Duren; Stefan
                      Holzmann, Erkelenz; Waltraut Hofmann, Achim Fritz, KfH
                      Linnich. In addition, the support of the following members
                      of the MRI group of the Institute of Neurosciences and
                      Medicine of the Research Center Julich is gratefully
                      acknowledged: Veronika Ermer, Heiko Neeb, and Cordula
                      Kemper.},
      abstract     = {Cognitive impairment is a common and largely undiagnosed
                      finding in a significant number of dialysis patients. These
                      alterations may result from concomitant cerebrovascular
                      disease, hemodynamic instability, the uremic milieu, or
                      changes induced by the dialysis process. In order to gain
                      further insight into this, we recruited 12 stable chronic
                      hemodialysis patients (without clinical neurological
                      disease) and an age- and gender-matched cohort of 12 control
                      individuals (without renal or neurological problems) in a
                      prospective, single-center study. In order to disentangle
                      the influence of dialysis itself on memory function, each
                      dialysis patient was tested twice: once immediately before
                      dialysis following a long weekend (t1) and again the day
                      after this dialysis (t2). The control individuals were
                      tested in the same time frame. Neuropsychological testing
                      found that the control individuals performed significantly
                      better in verbal learning, motor speed, task switching,
                      verbal comprehension, word fluency, spatial visualization,
                      spatial perception, and reasoning; all independent of the
                      time point. Functional magnetic resonance imaging of the
                      whole brain in seven hemodialysis patients found
                      significantly more bilateral activation of the hippocampus
                      during the verbal working memory task at t2 relative to t1
                      compared with their seven matched control counterparts.
                      Thus, our study found differential and task-specific
                      activation of memory-relevant brain areas during a dialysis
                      cycle.},
      keywords     = {Adult / Brain Mapping / Case-Control Studies / Cognition
                      Disorders: etiology / Female / Hippocampus: physiopathology
                      / Humans / Magnetic Resonance Imaging / Male / Memory:
                      physiology / Middle Aged / Neuropsychological Tests /
                      Prospective Studies / Renal Dialysis: adverse effects /
                      Verbal Learning / Young Adult / J (WoSType)},
      cin          = {INM-1 / INM-2 / INM-3 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Urology $\&$ Nephrology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20668428},
      UT           = {WOS:000282276200012},
      doi          = {10.1038/ki.2010.253},
      url          = {https://juser.fz-juelich.de/record/10798},
}