% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{PalomeroGallagher:10804,
      author       = {Palomero-Gallagher, N. and Schleicher, A. and Zilles, K.
                      and Löscher, W.},
      title        = {{T}he circling ci2 rat mutant revisited: receptor
                      architecture of the motor cortex},
      journal      = {Neuroscience},
      volume       = {170},
      issn         = {0306-4522},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-10804},
      pages        = {542 - 550},
      year         = {2010},
      note         = {This study was supported by the DFG (Lo 274/8-3). The
                      authors thank Prof. H.-J. Hedrich (Institute for Laboratory
                      Animal Science, Hannover Medical School, Germany) for
                      providing the ci2 mutants and LEW/Ztm controls. They also
                      wish to thank A. Borner, M. Cremer. S. Krause and S. Wilms
                      for their excellent technical assistance.},
      abstract     = {Circling behaviour of the ci2 rat mutant has been
                      associated with an abnormal laterality concerning
                      nigrostriatal and vestibular dopamine content and densities
                      of several neurotransmitter receptors. Since not only
                      subcortical, but also cortical activity subserve behavioural
                      asymmetry, we applied quantitative in vitro receptor
                      autoradiography to determine the densities of twenty
                      neurotransmitter receptors in three areas of the motor
                      cortex (Fr1, Fr2, Fr3) of the left and right hemispheres in
                      adult male circling mutant rats (ci2/ci2), non-circling
                      littermates (ci2/+) and aged-matched rats from the
                      background strain (LEW/Ztm, wild type). Rats had previously
                      been monitored for motor behaviour and swimming abilities.
                      Wild type and ci2/+ rats did not differ from the behavioural
                      point of view, whereas ci2/ci2 animals were characterized by
                      pronounced lateralized circling behaviour and were not able
                      to perform the swimming test correctly. Left Fr2 of wild
                      type rats contained significantly lower NMDA receptor
                      densities than its right counterpart. No interhemispheric
                      differences were found in the motor cortex of ci2/+ or
                      ci2/ci2 animals. All three areas of wild type rats contain
                      higher GABA(A) and adenosine A(1) receptor densities than
                      those of ci2/+ and ci2/ci2 animals, respectively. Serotonin
                      5-HT(2) receptor densities were significantly lower in the
                      motor cortex of ci2/ci2 animals than in that of their
                      heterozygous littermates. Thus, since the ci2 rat mutant
                      presents a wide range of behavioural and neurochemical
                      lateralization anomalies, in addition to representing a
                      model of Usher syndrome type 1, it may prove useful to
                      understand the mechanisms underlying abnormal rotational
                      behaviour and its relevance as a model of disturbances in
                      cerebral asymmetry and their consequences.},
      keywords     = {Animals / Autoradiography / Functional Laterality: genetics
                      / Heterozygote / Male / Motor Activity: genetics / Motor
                      Cortex: metabolism / Rats / Rats, Inbred Lew / Rats, Mutant
                      Strains / Receptors, Neurotransmitter: metabolism / Swimming
                      / Receptors, Neurotransmitter (NLM Chemicals) / J (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20674682},
      UT           = {WOS:000281939100016},
      doi          = {10.1016/j.neuroscience.2010.07.043},
      url          = {https://juser.fz-juelich.de/record/10804},
}