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| Hauptseite > Publikationsdatenbank > The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain > print |
| Hauptseite > Publikationsdatenbank > The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain > print |
| 001 | 10805 | ||
| 005 | 20210129210527.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:20665558 |
| 024 | 7 | _ | |2 DOI |a 10.1002/glia.21049 |
| 024 | 7 | _ | |2 WOS |a WOS:000284060900003 |
| 024 | 7 | _ | |a altmetric:3417440 |2 altmetric |
| 037 | _ | _ | |a PreJuSER-10805 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Neurosciences |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Keitel, V. |b 0 |
| 245 | _ | _ | |a The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain |
| 260 | _ | _ | |a Bognor Regis [u.a.] |b Wiley-Liss |c 2010 |
| 300 | _ | _ | |a 1794 - 1805 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 11101 |a Glia |v 58 |x 0894-1491 |
| 500 | _ | _ | |a Grant sponsor: Deutsche Forschungsgemeinschaft through Sonderforschungsbereich 575 Dusseldorf "Experimental Hepatology.". |
| 520 | _ | _ | |a TGR5 (Gpbar-1) is a membrane-bound bile acid receptor in the gastrointestinal tract and immune cells with pleiotropic actions. As shown in the present study, TGR5 is also expressed in astrocytes and neurons. Here, TGR5 may act as a neurosteroid receptor, which is activated by nanomolar concentrations of 5β-pregnan-3α-ol-20-one and micromolar concentrations of 5β-pregnan-3α-17α-21-triol-20-one and 5α-pregnan-3α-ol-20-one (allopregnanolone). TGR5 stimulation in astrocytes and neurons is coupled to adenylate cyclase activation, elevation of intracellular Ca(2+) and the generation of reactive oxygen species. In cultured rat astrocytes, TGR5 mRNA is downregulated in the presence of neurosteroids and ammonia already at concentrations of 0.5 mmol L(-1). Furthermore, TGR5 protein levels are significantly reduced in isolated rat astrocytes after incubation with ammonia. A marked downregulation of TGR5 mRNA is also found in cerebral cortex from cirrhotic patients dying with hepatic encephalopathy (HE) when compared with brains from noncirrhotic control subjects. It is concluded that TGR5 is a novel neurosteroid receptor in brain with implications for the pathogenesis of HE. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK409 |2 G:(DE-HGF) |x 0 |c FUEK409 |a Funktion und Dysfunktion des Nervensystems (FUEK409) |
| 536 | _ | _ | |0 G:(DE-HGF)POF2-89571 |a 89571 - Connectivity and Activity (POF2-89571) |c POF2-89571 |f POF II T |x 1 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Animals |
| 650 | _ | 2 | |2 MeSH |a Animals, Newborn |
| 650 | _ | 2 | |2 MeSH |a Astrocytes: drug effects |
| 650 | _ | 2 | |2 MeSH |a Astrocytes: metabolism |
| 650 | _ | 2 | |2 MeSH |a Brain: cytology |
| 650 | _ | 2 | |2 MeSH |a Brain: metabolism |
| 650 | _ | 2 | |2 MeSH |a CREB-Binding Protein: metabolism |
| 650 | _ | 2 | |2 MeSH |a Calcium: metabolism |
| 650 | _ | 2 | |2 MeSH |a Cells, Cultured |
| 650 | _ | 2 | |2 MeSH |a Cholagogues and Choleretics: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Coculture Techniques |
| 650 | _ | 2 | |2 MeSH |a Cyclic AMP: metabolism |
| 650 | _ | 2 | |2 MeSH |a Dose-Response Relationship, Drug |
| 650 | _ | 2 | |2 MeSH |a Forskolin: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Gene Expression Regulation: drug effects |
| 650 | _ | 2 | |2 MeSH |a Gene Expression Regulation: physiology |
| 650 | _ | 2 | |2 MeSH |a Glial Fibrillary Acidic Protein: metabolism |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Luminescent Proteins |
| 650 | _ | 2 | |2 MeSH |a Microtubule-Associated Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Neurons: drug effects |
| 650 | _ | 2 | |2 MeSH |a Neurons: metabolism |
| 650 | _ | 2 | |2 MeSH |a Neurotransmitter Agents: pharmacology |
| 650 | _ | 2 | |2 MeSH |a RNA, Messenger: metabolism |
| 650 | _ | 2 | |2 MeSH |a Rats |
| 650 | _ | 2 | |2 MeSH |a Rats, Wistar |
| 650 | _ | 2 | |2 MeSH |a Reactive Oxygen Species: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptors, G-Protein-Coupled: antagonists & inhibitors |
| 650 | _ | 2 | |2 MeSH |a Receptors, G-Protein-Coupled: genetics |
| 650 | _ | 2 | |2 MeSH |a Receptors, G-Protein-Coupled: physiology |
| 650 | _ | 2 | |2 MeSH |a Statistics, Nonparametric |
| 650 | _ | 2 | |2 MeSH |a Taurolithocholic Acid: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Transfection: methods |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Cholagogues and Choleretics |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Crebbp protein, rat |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Glial Fibrillary Acidic Protein |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Gpbar1 protein, rat |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Luminescent Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Microtubule-Associated Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Mtap2 protein, rat |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Neurotransmitter Agents |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a RNA, Messenger |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Reactive Oxygen Species |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, G-Protein-Coupled |
| 650 | _ | 7 | |0 516-90-5 |2 NLM Chemicals |a Taurolithocholic Acid |
| 650 | _ | 7 | |0 60-92-4 |2 NLM Chemicals |a Cyclic AMP |
| 650 | _ | 7 | |0 66428-89-5 |2 NLM Chemicals |a Forskolin |
| 650 | _ | 7 | |0 7440-70-2 |2 NLM Chemicals |a Calcium |
| 650 | _ | 7 | |0 EC 2.3.1.48 |2 NLM Chemicals |a CREB-Binding Protein |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a hepatic encephalopathy |
| 653 | 2 | 0 | |2 Author |a astrocyte |
| 653 | 2 | 0 | |2 Author |a ammonia |
| 653 | 2 | 0 | |2 Author |a neuron |
| 653 | 2 | 0 | |2 Author |a calcium |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Görg, B. |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Bidmon, H.J. |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Zemtsova, I. |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Sporner, L. |b 4 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131714 |a Zilles, K. |b 5 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB9577 |a Häussinger, D. |b 6 |u FZJ |
| 773 | _ | _ | |0 PERI:(DE-600)1474828-9 |a 10.1002/glia.21049 |g Vol. 58, p. 1794 - 1805 |p 1794 - 1805 |q 58<1794 - 1805 |t Glia |v 58 |x 0894-1491 |y 2010 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1002/glia.21049 |
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| 914 | 1 | _ | |y 2010 |
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