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000010821 0247_ $$2DOI$$a10.1016/j.neuroimgage.2010.07.054
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000010821 041__ $$aeng
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000010821 084__ $$2WoS$$aNeurosciences
000010821 084__ $$2WoS$$aNeuroimaging
000010821 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000010821 1001_ $$0P:(DE-HGF)0$$aPapadelis, C.$$b0
000010821 245__ $$aBA3b and BA1 activate in a serial fashion after median nerve stimulation: Direct evidence from combining source analysis of evoked fields and cytoarchitectonic probabilistic maps
000010821 260__ $$aOrlando, Fla.$$bAcademic Press$$c2011
000010821 300__ $$a60 - 73
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000010821 440_0 $$04545$$aNeuroImage$$v54$$x1053-8119
000010821 500__ $$aWe thank all the staff of the Laboratory for Human Brain Dynamics (1999-2009) at the Brain Science Institute, RIKEN and especially Mr. Kenji Haruhana for the assistance with the experiment. The experiment and data analysis were performed at RIKEN and the work was continued by the authors at their new posts in Italy and Cyprus. Following the closing of the MEG laboratory at RIKEN in September 2009, the contribution from AAI was supported by Cyprus Research Promotion Foundation grants (upgrade/info/0308/02 and human/sociol/0308/BE). SBE was supported by the Human Brain Project (R01-MH074457-01A1), and SBE and KZ by the Helmholtz Initiative on Systems Biology "The Human Brain Model".
000010821 520__ $$aThis study combines source analysis imaging data for early somatosensory processing and the probabilistic cytoarchitectonic maps (PCMs). Human somatosensory evoked fields (SEFs) were recorded by stimulating left and right median nerves. Filtering the recorded responses in different frequency ranges identified the most responsive frequency band. The short-latency averaged SEFs were analyzed using a single equivalent current dipole (ECD) model and magnetic field tomography (MET). The identified foci of activity were superimposed with PCMs. Two major components of opposite polarity were prominent around 21 and 31 ms. A weak component around 25 ms was also identified. For the most responsive frequency band (50-150 Hz) ECD and MFT revealed one focal source at the contralateral Brodmann area 3b (BA3b) at the peak of N20. The component similar to 25 ms was localised in Brodmann area 1 (BA1) in 50-150 Hz. By using ECD, focal generators around 28-30 ms located initially in BA3b and 2 ms later to BA1. MET also revealed two focal sources one in BA3b and one in BA1 for these latencies. Our results provide direct evidence that the earliest cortical response after median nerve stimulation is generated within the contralateral BA3b. BA1 activation few milliseconds later indicates a serial mode of somatosensory processing within cytoarchitectonic SI subdivisions. Analysis of non-invasive magnetoencephalography (MEG) data and the use of PCMs allow unambiguous and quantitative (probabilistic) interpretation of cytoarchitectonic identity of activated areas following median nerve stimulation, even with the simple ECD model, but only when the model fits the data extremely well. (C) 2010 Elsevier Inc. All rights reserved.
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000010821 65320 $$2Author$$aSomatosensory evoked fields
000010821 65320 $$2Author$$aSerial processing
000010821 65320 $$2Author$$aMedian nerve
000010821 65320 $$2Author$$aCytoarchitectonic probabilistic maps
000010821 650_7 $$2WoSType$$aJ
000010821 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b1$$uFZJ
000010821 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b2$$uFZJ
000010821 7001_ $$0P:(DE-HGF)0$$aIoannides, A.A.$$b3
000010821 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimgage.2010.07.054$$gVol. 54, p. 60 - 73$$p60 - 73$$q54<60 - 73$$tNeuroImage$$v54$$x1053-8119$$y2011
000010821 8567_ $$uhttp://dx.doi.org/10.1016/j.neuroimgage.2010.07.054
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