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@ARTICLE{Papadelis:10821,
      author       = {Papadelis, C. and Eickhoff, S. B. and Zilles, K. and
                      Ioannides, A.A.},
      title        = {{BA}3b and {BA}1 activate in a serial fashion after median
                      nerve stimulation: {D}irect evidence from combining source
                      analysis of evoked fields and cytoarchitectonic
                      probabilistic maps},
      journal      = {NeuroImage},
      volume       = {54},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {PreJuSER-10821},
      pages        = {60 - 73},
      year         = {2011},
      note         = {We thank all the staff of the Laboratory for Human Brain
                      Dynamics (1999-2009) at the Brain Science Institute, RIKEN
                      and especially Mr. Kenji Haruhana for the assistance with
                      the experiment. The experiment and data analysis were
                      performed at RIKEN and the work was continued by the authors
                      at their new posts in Italy and Cyprus. Following the
                      closing of the MEG laboratory at RIKEN in September 2009,
                      the contribution from AAI was supported by Cyprus Research
                      Promotion Foundation grants (upgrade/info/0308/02 and
                      human/sociol/0308/BE). SBE was supported by the Human Brain
                      Project (R01-MH074457-01A1), and SBE and KZ by the Helmholtz
                      Initiative on Systems Biology "The Human Brain Model".},
      abstract     = {This study combines source analysis imaging data for early
                      somatosensory processing and the probabilistic
                      cytoarchitectonic maps (PCMs). Human somatosensory evoked
                      fields (SEFs) were recorded by stimulating left and right
                      median nerves. Filtering the recorded responses in different
                      frequency ranges identified the most responsive frequency
                      band. The short-latency averaged SEFs were analyzed using a
                      single equivalent current dipole (ECD) model and magnetic
                      field tomography (MET). The identified foci of activity were
                      superimposed with PCMs. Two major components of opposite
                      polarity were prominent around 21 and 31 ms. A weak
                      component around 25 ms was also identified. For the most
                      responsive frequency band (50-150 Hz) ECD and MFT revealed
                      one focal source at the contralateral Brodmann area 3b
                      (BA3b) at the peak of N20. The component similar to 25 ms
                      was localised in Brodmann area 1 (BA1) in 50-150 Hz. By
                      using ECD, focal generators around 28-30 ms located
                      initially in BA3b and 2 ms later to BA1. MET also revealed
                      two focal sources one in BA3b and one in BA1 for these
                      latencies. Our results provide direct evidence that the
                      earliest cortical response after median nerve stimulation is
                      generated within the contralateral BA3b. BA1 activation few
                      milliseconds later indicates a serial mode of somatosensory
                      processing within cytoarchitectonic SI subdivisions.
                      Analysis of non-invasive magnetoencephalography (MEG) data
                      and the use of PCMs allow unambiguous and quantitative
                      (probabilistic) interpretation of cytoarchitectonic identity
                      of activated areas following median nerve stimulation, even
                      with the simple ECD model, but only when the model fits the
                      data extremely well. (C) 2010 Elsevier Inc. All rights
                      reserved.},
      keywords     = {J (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000283825000009},
      doi          = {10.1016/j.neuroimgage.2010.07.054},
      url          = {https://juser.fz-juelich.de/record/10821},
}