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000010934 0247_ $$2DOI$$a10.1016/j.schres.2010.07.023
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000010934 041__ $$aeng
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000010934 084__ $$2WoS$$aPsychiatry
000010934 1001_ $$0P:(DE-HGF)0$$aBarbour, T.$$b0
000010934 245__ $$aReduced intra-amygdala activity to positively valenced faces in adolescent schizophrenia offspring
000010934 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2010
000010934 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010934 3367_ $$2BibTeX$$aARTICLE
000010934 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000010934 3367_ $$2DRIVER$$aarticle
000010934 440_0 $$05427$$aSchizophrenia Research$$v123$$x0920-9964$$y126 - 136
000010934 500__ $$aThis research was supported by grants from the National Institute of Mental Health (MH68680) and the Children's Research of Michigan (CRCM) to VAD. TB was supported by the Joseph Young Jr. Fund. The funding sources had no role in study design: in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
000010934 520__ $$aStudies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to neuronal responses within the limbic system are poorly understood. The amygdala is the central region devoted to the processing of emotional valence and its sub-nuclei including the baso-lateral and centro-medial are organized in a relative hierarchy of affective processing. Outputs from the centro-medial nucleus converge on regions involved in the autonomous regulation of behavior, and outputs from the baso-lateral nucleus modulate the response of reward processing regions. Here using fMRI we assessed the intra-amygdala response to positive, negative, and neutral valenced faces in a group of controls (with no family history of psychosis) and offspring of schizophrenia parents (n=44 subjects in total). Subjects performed an affective continuous performance task during which they continually appraised whether the affect signaled by a face on a given trial was the same or different from the previous trial (regardless of facial identity). Relative to controls, offspring showed reduced activity in the left centro-medial nucleus to positively (but not negatively or neutral) valenced faces. These results were independent of behavioral/cognitive performance (equal across groups) suggesting that an impaired affective substrate in the intra-amygdala response may lie at the core of deficits of social behavior that have been documented in this population.
000010934 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000010934 536__ $$0G:(DE-HGF)POF2-89572$$a89572 - (Dys-)function and Plasticity (POF2-89572)$$cPOF2-89572$$fPOF II T$$x1
000010934 588__ $$aDataset connected to Web of Science, Pubmed
000010934 65320 $$2Author$$aDevelopment
000010934 65320 $$2Author$$aAffective response
000010934 65320 $$2Author$$aVulnerability
000010934 65320 $$2Author$$aCentro-medial nucleus
000010934 65320 $$2Author$$aBaso-lateral nucleus
000010934 65320 $$2Author$$aReward
000010934 650_2 $$2MeSH$$aAdolescent
000010934 650_2 $$2MeSH$$aAdolescent Psychology
000010934 650_2 $$2MeSH$$aAffect
000010934 650_2 $$2MeSH$$aAmygdala: physiopathology
000010934 650_2 $$2MeSH$$aChild of Impaired Parents: psychology
000010934 650_2 $$2MeSH$$aEmotions
000010934 650_2 $$2MeSH$$aFacial Expression
000010934 650_2 $$2MeSH$$aFemale
000010934 650_2 $$2MeSH$$aFunctional Laterality
000010934 650_2 $$2MeSH$$aHumans
000010934 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000010934 650_2 $$2MeSH$$aMale
000010934 650_2 $$2MeSH$$aNeuropsychological Tests
000010934 650_2 $$2MeSH$$aPattern Recognition, Visual
000010934 650_2 $$2MeSH$$aSchizophrenia: etiology
000010934 650_2 $$2MeSH$$aSchizophrenia: genetics
000010934 650_7 $$2WoSType$$aJ
000010934 7001_ $$0P:(DE-HGF)0$$aMurphy, E.$$b1
000010934 7001_ $$0P:(DE-HGF)0$$aPruitt, P.$$b2
000010934 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b3$$uFZJ
000010934 7001_ $$0P:(DE-HGF)0$$aKeshavan, M.S.$$b4
000010934 7001_ $$0P:(DE-HGF)0$$aRajan, U.$$b5
000010934 7001_ $$0P:(DE-HGF)0$$aZajac-Benitez, C.$$b6
000010934 7001_ $$0P:(DE-HGF)0$$aDiwadkar, V.A.$$b7
000010934 773__ $$0PERI:(DE-600)1500726-1$$a10.1016/j.schres.2010.07.023$$gVol. 123$$q123$$tSchizophrenia research$$v123$$x0920-9964$$y2010
000010934 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174012
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