TY  - JOUR
AU  - Barbour, T.
AU  - Murphy, E.
AU  - Pruitt, P.
AU  - Eickhoff, S. B.
AU  - Keshavan, M.S.
AU  - Rajan, U.
AU  - Zajac-Benitez, C.
AU  - Diwadkar, V.A.
TI  - Reduced intra-amygdala activity to positively valenced faces in adolescent schizophrenia offspring
JO  - Schizophrenia research
VL  - 123
SN  - 0920-9964
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-10934
PY  - 2010
N1  - This research was supported by grants from the National Institute of Mental Health (MH68680) and the Children's Research of Michigan (CRCM) to VAD. TB was supported by the Joseph Young Jr. Fund. The funding sources had no role in study design: in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
AB  - Studies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to neuronal responses within the limbic system are poorly understood. The amygdala is the central region devoted to the processing of emotional valence and its sub-nuclei including the baso-lateral and centro-medial are organized in a relative hierarchy of affective processing. Outputs from the centro-medial nucleus converge on regions involved in the autonomous regulation of behavior, and outputs from the baso-lateral nucleus modulate the response of reward processing regions. Here using fMRI we assessed the intra-amygdala response to positive, negative, and neutral valenced faces in a group of controls (with no family history of psychosis) and offspring of schizophrenia parents (n=44 subjects in total). Subjects performed an affective continuous performance task during which they continually appraised whether the affect signaled by a face on a given trial was the same or different from the previous trial (regardless of facial identity). Relative to controls, offspring showed reduced activity in the left centro-medial nucleus to positively (but not negatively or neutral) valenced faces. These results were independent of behavioral/cognitive performance (equal across groups) suggesting that an impaired affective substrate in the intra-amygdala response may lie at the core of deficits of social behavior that have been documented in this population.
KW  - Adolescent
KW  - Adolescent Psychology
KW  - Affect
KW  - Amygdala: physiopathology
KW  - Child of Impaired Parents: psychology
KW  - Emotions
KW  - Facial Expression
KW  - Female
KW  - Functional Laterality
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Neuropsychological Tests
KW  - Pattern Recognition, Visual
KW  - Schizophrenia: etiology
KW  - Schizophrenia: genetics
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20716480
C2  - pmc:PMC3174012
UR  - <Go to ISI:>//WOS:000284795700004
DO  - DOI:10.1016/j.schres.2010.07.023
UR  - https://juser.fz-juelich.de/record/10934
ER  -