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@ARTICLE{Barbour:10934,
      author       = {Barbour, T. and Murphy, E. and Pruitt, P. and Eickhoff, S.
                      B. and Keshavan, M.S. and Rajan, U. and Zajac-Benitez, C.
                      and Diwadkar, V.A.},
      title        = {{R}educed intra-amygdala activity to positively valenced
                      faces in adolescent schizophrenia offspring},
      journal      = {Schizophrenia research},
      volume       = {123},
      issn         = {0920-9964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-10934},
      year         = {2010},
      note         = {This research was supported by grants from the National
                      Institute of Mental Health (MH68680) and the Children's
                      Research of Michigan (CRCM) to VAD. TB was supported by the
                      Joseph Young Jr. Fund. The funding sources had no role in
                      study design: in the collection, analysis and interpretation
                      of data; in the writing of the report; or in the decision to
                      submit the paper for publication.},
      abstract     = {Studies suggest that the affective response is impaired in
                      both schizophrenia and adolescent offspring of schizophrenia
                      patients. Adolescent offspring of patients are
                      developmentally vulnerable to impairments in several
                      domains, including affective responding, yet the bases of
                      these impairments and their relation to neuronal responses
                      within the limbic system are poorly understood. The amygdala
                      is the central region devoted to the processing of emotional
                      valence and its sub-nuclei including the baso-lateral and
                      centro-medial are organized in a relative hierarchy of
                      affective processing. Outputs from the centro-medial nucleus
                      converge on regions involved in the autonomous regulation of
                      behavior, and outputs from the baso-lateral nucleus modulate
                      the response of reward processing regions. Here using fMRI
                      we assessed the intra-amygdala response to positive,
                      negative, and neutral valenced faces in a group of controls
                      (with no family history of psychosis) and offspring of
                      schizophrenia parents (n=44 subjects in total). Subjects
                      performed an affective continuous performance task during
                      which they continually appraised whether the affect signaled
                      by a face on a given trial was the same or different from
                      the previous trial (regardless of facial identity). Relative
                      to controls, offspring showed reduced activity in the left
                      centro-medial nucleus to positively (but not negatively or
                      neutral) valenced faces. These results were independent of
                      behavioral/cognitive performance (equal across groups)
                      suggesting that an impaired affective substrate in the
                      intra-amygdala response may lie at the core of deficits of
                      social behavior that have been documented in this
                      population.},
      keywords     = {Adolescent / Adolescent Psychology / Affect / Amygdala:
                      physiopathology / Child of Impaired Parents: psychology /
                      Emotions / Facial Expression / Female / Functional
                      Laterality / Humans / Magnetic Resonance Imaging / Male /
                      Neuropsychological Tests / Pattern Recognition, Visual /
                      Schizophrenia: etiology / Schizophrenia: genetics / J
                      (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20716480},
      pmc          = {pmc:PMC3174012},
      UT           = {WOS:000284795700004},
      doi          = {10.1016/j.schres.2010.07.023},
      url          = {https://juser.fz-juelich.de/record/10934},
}