Hauptseite > Publikationsdatenbank > Reduced intra-amygdala activity to positively valenced faces in adolescent schizophrenia offspring > print

001     10934
005     20210129210531.0
024 7 _ |2 pmid
|a pmid:20716480
024 7 _ |2 pmc
|a pmc:PMC3174012
024 7 _ |2 DOI
|a 10.1016/j.schres.2010.07.023
024 7 _ |2 WOS
|a WOS:000284795700004
037 _ _ |a PreJuSER-10934
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Psychiatry
100 1 _ |0 P:(DE-HGF)0
|a Barbour, T.
|b 0
245 _ _ |a Reduced intra-amygdala activity to positively valenced faces in adolescent schizophrenia offspring
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2010
336 7 _ |0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
|a Journal Article
336 7 _ |2 DataCite
|a Output Types/Journal article
336 7 _ |0 0
|2 EndNote
|a Journal Article
336 7 _ |2 BibTeX
|a ARTICLE
336 7 _ |2 ORCID
|a JOURNAL_ARTICLE
336 7 _ |2 DRIVER
|a article
440 _ 0 |0 5427
|a Schizophrenia Research
|v 123
|x 0920-9964
|y 126 - 136
500 _ _ |a This research was supported by grants from the National Institute of Mental Health (MH68680) and the Children's Research of Michigan (CRCM) to VAD. TB was supported by the Joseph Young Jr. Fund. The funding sources had no role in study design: in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
520 _ _ |a Studies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to neuronal responses within the limbic system are poorly understood. The amygdala is the central region devoted to the processing of emotional valence and its sub-nuclei including the baso-lateral and centro-medial are organized in a relative hierarchy of affective processing. Outputs from the centro-medial nucleus converge on regions involved in the autonomous regulation of behavior, and outputs from the baso-lateral nucleus modulate the response of reward processing regions. Here using fMRI we assessed the intra-amygdala response to positive, negative, and neutral valenced faces in a group of controls (with no family history of psychosis) and offspring of schizophrenia parents (n=44 subjects in total). Subjects performed an affective continuous performance task during which they continually appraised whether the affect signaled by a face on a given trial was the same or different from the previous trial (regardless of facial identity). Relative to controls, offspring showed reduced activity in the left centro-medial nucleus to positively (but not negatively or neutral) valenced faces. These results were independent of behavioral/cognitive performance (equal across groups) suggesting that an impaired affective substrate in the intra-amygdala response may lie at the core of deficits of social behavior that have been documented in this population.
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|c FUEK409
|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |0 G:(DE-HGF)POF2-89572
|a 89572 - (Dys-)function and Plasticity (POF2-89572)
|c POF2-89572
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adolescent
650 _ 2 |2 MeSH
|a Adolescent Psychology
650 _ 2 |2 MeSH
|a Affect
650 _ 2 |2 MeSH
|a Amygdala: physiopathology
650 _ 2 |2 MeSH
|a Child of Impaired Parents: psychology
650 _ 2 |2 MeSH
|a Emotions
650 _ 2 |2 MeSH
|a Facial Expression
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Functional Laterality
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Neuropsychological Tests
650 _ 2 |2 MeSH
|a Pattern Recognition, Visual
650 _ 2 |2 MeSH
|a Schizophrenia: etiology
650 _ 2 |2 MeSH
|a Schizophrenia: genetics
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a Development
653 2 0 |2 Author
|a Affective response
653 2 0 |2 Author
|a Vulnerability
653 2 0 |2 Author
|a Centro-medial nucleus
653 2 0 |2 Author
|a Baso-lateral nucleus
653 2 0 |2 Author
|a Reward
700 1 _ |0 P:(DE-HGF)0
|a Murphy, E.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Pruitt, P.
|b 2
700 1 _ |0 P:(DE-Juel1)131678
|a Eickhoff, S. B.
|b 3
|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Keshavan, M.S.
|b 4
700 1 _ |0 P:(DE-HGF)0
|a Rajan, U.
|b 5
700 1 _ |0 P:(DE-HGF)0
|a Zajac-Benitez, C.
|b 6
700 1 _ |0 P:(DE-HGF)0
|a Diwadkar, V.A.
|b 7
773 _ _ |0 PERI:(DE-600)1500726-1
|a 10.1016/j.schres.2010.07.023
|g Vol. 123
|q 123
|t Schizophrenia research
|v 123
|x 0920-9964
|y 2010
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174012
909 C O |o oai:juser.fz-juelich.de:10934
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