%0 Journal Article
%A Gilles, S.
%A Winter, S.
%A Michael, K. E.
%A Meffert, S.
%A Li, P.
%A Greben, K.
%A Simon, U.
%A Offenhäusser, A.
%A Mayer, D.
%T Control of Cell Adhesion and Neurite Outgrowth by Patterned Gold Nanoparticles with Tunable Attractive or Repulsive Surface Properties
%J Small
%V 8
%@ 1613-6810
%C Weinheim
%I Wiley-VCH Verl.
%M PreJuSER-111856
%P 3357 - 3367
%D 2012
%Z Record converted from VDB: 16.11.2012
%X Guiding of neuronal cells on surfaces is required for the investigation of fundamental aspects of neurobiology, for tissue engineering, and for numerous bioelectronic applications. A modular method to establish nanostructured chemical templates for local deposition of gold nanoparticles is presented. A process comprising nanoimprint lithography, silanization, lift-off, and gold nanoparticle immobilization is used to fabricate the particle patterns. The chemical composition of the surface can be modified by in situ adsorption of cell-binding ligands to locally addressed particles. The versatility of this approach is demonstrated by inverting the binding affinity between rat cortical neurons and nanopatterned surfaces via wet-chemical means and thereby reversing the pattern of guided neurons.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22826008
%U <Go to ISI:>//WOS:000310600600016
%R 10.1002/smll.201200465
%U https://juser.fz-juelich.de/record/111856