TY  - JOUR
AU  - Gilles, S.
AU  - Winter, S.
AU  - Michael, K. E.
AU  - Meffert, S.
AU  - Li, P.
AU  - Greben, K.
AU  - Simon, U.
AU  - Offenhäusser, A.
AU  - Mayer, D.
TI  - Control of Cell Adhesion and Neurite Outgrowth by Patterned Gold Nanoparticles with Tunable Attractive or Repulsive Surface Properties
JO  - Small
VL  - 8
SN  - 1613-6810
CY  - Weinheim
PB  - Wiley-VCH Verl.
M1  - PreJuSER-111856
SP  - 3357 - 3367
PY  - 2012
N1  - Record converted from VDB: 16.11.2012
AB  - Guiding of neuronal cells on surfaces is required for the investigation of fundamental aspects of neurobiology, for tissue engineering, and for numerous bioelectronic applications. A modular method to establish nanostructured chemical templates for local deposition of gold nanoparticles is presented. A process comprising nanoimprint lithography, silanization, lift-off, and gold nanoparticle immobilization is used to fabricate the particle patterns. The chemical composition of the surface can be modified by in situ adsorption of cell-binding ligands to locally addressed particles. The versatility of this approach is demonstrated by inverting the binding affinity between rat cortical neurons and nanopatterned surfaces via wet-chemical means and thereby reversing the pattern of guided neurons.
LB  - PUB:(DE-HGF)16
C6  - pmid:22826008
UR  - <Go to ISI:>//WOS:000310600600016
DO  - DOI:10.1002/smll.201200465
UR  - https://juser.fz-juelich.de/record/111856
ER  -