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@ARTICLE{Sabir:111910,
      author       = {Sabir, T. and Toulmin, A. and Ma, L. and Jones, A.C. and
                      McGlynn, P. and Schröder, G.F. and Magennis, S.W.},
      title        = {{B}ranchpoint expansion in a fully-complementary three-way
                      {DNA} junction.},
      journal      = {Journal of the American Chemical Society},
      volume       = {134},
      issn         = {0002-7863},
      address      = {Washington, DC},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-111910},
      pages        = {6280 - 6285},
      year         = {2012},
      note         = {We thank the BBSRC for support (BB/G00269X/1); Claus
                      Seidel, Ralf Kuhnemuth, and Stefan Marawske for assistance
                      in developing our MFD setup; Suren Felekyan for help with
                      data analysis; and Jochen Ark for assistance with
                      experiments. S.W.M. acknowledges the award of an EPSRC
                      advanced research fellowship (EP/D073154), and L.M.
                      acknowledges the award of a CSC scholarship.},
      abstract     = {Branched nucleic acid molecules serve as key intermediates
                      in DNA replication, recombination, and repair; architectural
                      elements in RNA; and building blocks and functional
                      components for nanoscience applications. Using a combination
                      of high-resolution single-molecule FRET, time-resolved
                      spectroscopy, and molecular modeling, we have probed the
                      local and global structure of a DNA three-way junction (3WJ)
                      in solution. We found that it adopts a Y-shaped, pyramidal
                      structure, in which the bases adjacent to the branchpoint
                      are unpaired, despite the full Watson-Crick complementarity
                      of the molecule. The unpairing allows a nanoscale cavity to
                      form at the junction center. Our structure accounts for
                      earlier observations made of the structure, flexibility, and
                      reactivity of 3WJs. We anticipate that these results will
                      guide the development of new DNA-based supramolecular
                      receptors and nanosystems.},
      keywords     = {Computer Simulation / DNA: chemistry / Fluorescence
                      Resonance Energy Transfer: methods / Hydrogen Bonding / Ions
                      / Kinetics / Molecular Dynamics Simulation / Nanotechnology:
                      methods / Nucleic Acid Conformation / Nucleic Acids /
                      Nucleotides: chemistry / RNA: chemistry / Reproducibility of
                      Results / Spectrophotometry: methods / Ions (NLM Chemicals)
                      / Nucleic Acids (NLM Chemicals) / Nucleotides (NLM
                      Chemicals) / RNA (NLM Chemicals) / DNA (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {Funktion und Dysfunktion des Nervensystems / BioSoft:
                      Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK505},
      shelfmark    = {Chemistry, Multidisciplinary},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22329743},
      UT           = {WOS:000302524800037},
      doi          = {10.1021/ja211802z},
      url          = {https://juser.fz-juelich.de/record/111910},
}