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@ARTICLE{Greimel:112082,
      author       = {Greimel, E. and Nehrkorn, B. and Fink, G.R. and Kukolja, J.
                      and Kohls, G. and Müller, K. and Piefke, M. and
                      Kamp-Becker, I. and Remschmidt, H. and Herpertz-Dahlman, B.
                      and Konrad, K. and Schulte-Rüther, M.},
      title        = {{N}eural mechanisms of encoding social and non-social
                      context information in autism spectrum disorder},
      journal      = {Neuropsychologia},
      volume       = {50},
      issn         = {0028-3932},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-112082},
      pages        = {3440- 3449},
      year         = {2012},
      note         = {Record converted from VDB: 16.11.2012},
      abstract     = {Individuals with autism spectrum disorder (ASD) often fail
                      to attach context to their memories and are specifically
                      impaired in processing social aspects of contextual
                      information. The aim of the present study was to investigate
                      the modulatory influence of social vs. non-social context on
                      neural mechanisms during encoding in ASD. Using
                      event-related fMRI, 13 boys with ASD and 13 typically
                      developing boys comparable for age and IQ were investigated
                      during encoding of neutral objects presented either with a
                      social (faces) or a non-social (houses) context. A memory
                      paradigm was then applied to identify brain activation
                      patterns associated with encoding of subsequently
                      recollected versus non-recollected objects. On the
                      behavioural level, no significant between-group differences
                      emerged. In particular, no differential effects of context
                      on memory performance were observed. Neurally, however,
                      context-specific group differences were observed in several
                      brain regions. During encoding of subsequently recollected
                      objects presented with a face, ASD subjects (compared to
                      controls) showed reduced neural activation in the bilateral
                      inferior frontal gyrus, bilateral middle frontal gyrus and
                      right inferior parietal lobule. Neural activation in the
                      right inferior frontal gyrus was positively correlated with
                      memory performance in controls, but negatively in ASD
                      individuals. During encoding of subsequently non-recollected
                      objects presented in the non-social context, ASD subjects
                      showed increased activation in the dorsal MPFC. Our findings
                      suggest that in ASD subjects, fronto-parietal brain regions
                      subserving memory formation and the association of
                      contextual information are activated atypically when a
                      social context is presented at encoding. The data add to
                      findings from related research fields indicating that in
                      ASD, socioemotional impairment extends into domains beyond
                      social cognition. Increased activation in the dorsal MPFC in
                      ASD individuals might reflect supervisory cognitive
                      processes related to the suppression of a distracting
                      non-social context.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23017597},
      UT           = {WOS:000313142700029},
      doi          = {10.1016/j.neuropsychologia.2012.09.029},
      url          = {https://juser.fz-juelich.de/record/112082},
}