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000011234 0247_ $$2DOI$$a10.1016/j.neuroimage.2010.07.009
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000011234 084__ $$2WoS$$aNeurosciences
000011234 084__ $$2WoS$$aNeuroimaging
000011234 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000011234 1001_ $$0P:(DE-Juel1)VDB33807$$aHeim, S.$$b0$$uFZJ
000011234 245__ $$aCognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children
000011234 260__ $$aOrlando, Fla.$$bAcademic Press$$c2010
000011234 300__ $$a1346 - 1358
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000011234 440_0 $$04545$$aNeuroImage$$v53$$x1053-8119$$y4
000011234 500__ $$aThis research was supported by the German Federal Ministry of Education and Research (BMBF 01GJ0613 to S.H. and BMBF 01GJ0614 to M.G.), the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health (K.A.).
000011234 520__ $$aRecent theories of developmental dyslexia explain reading deficits in terms of deficient phonological awareness, attention, visual and auditory processing, or automaticity. Since dyslexia has a neurobiological basis, the question arises how the reader's proficiency in these cognitive variables affects the brain regions involved in visual word recognition. This question was addressed in two fMRI experiments with 19 normally reading children (Experiment 1) and 19 children with dyslexia (Experiment 2). First, reading-specific brain activation was assessed by contrasting the BOLD signal for reading aloud words vs. overtly naming pictures of real objects. Next, ANCOVAs with brain activation during reading the individuals' scores for all five cognitive variables assessed outside the scanner as covariates were performed. Whereas the normal readers' brain activation during reading showed co-variation effects predominantly in the right hemisphere, the reverse pattern was observed for the dyslexics. In particular, middle frontal gyrus, inferior parietal cortex, and precuneus showed contralateral effects for controls as compared to dyslexics. In line with earlier findings in the literature, these data hint at a global change in hemispheric asymmetry during cognitive processing in dyslexic readers, which, in turn, might affect reading proficiency.
000011234 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000011234 650_2 $$2MeSH$$aBrain: physiology
000011234 650_2 $$2MeSH$$aBrain Mapping
000011234 650_2 $$2MeSH$$aChild
000011234 650_2 $$2MeSH$$aCognition: physiology
000011234 650_2 $$2MeSH$$aDyslexia: physiopathology
000011234 650_2 $$2MeSH$$aFemale
000011234 650_2 $$2MeSH$$aFunctional Laterality: physiology
000011234 650_2 $$2MeSH$$aHumans
000011234 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000011234 650_2 $$2MeSH$$aMale
000011234 650_2 $$2MeSH$$aReading
000011234 650_7 $$2WoSType$$aJ
000011234 7001_ $$0P:(DE-HGF)0$$aGrande, M.$$b1
000011234 7001_ $$0P:(DE-Juel1)VDB93695$$aMeffert, E.$$b2$$uFZJ
000011234 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b3$$uFZJ
000011234 7001_ $$0P:(DE-Juel1)VDB84395$$aSchreiber, H.$$b4$$uFZJ
000011234 7001_ $$0P:(DE-Juel1)131730$$aKukolja, J.$$b5$$uFZJ
000011234 7001_ $$0P:(DE-Juel1)131794$$aShah, J. N.$$b6$$uFZJ
000011234 7001_ $$0P:(DE-HGF)0$$aHuber, W.$$b7
000011234 7001_ $$0P:(DE-Juel1)131631$$aAmunts, K.$$b8$$uFZJ
000011234 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2010.07.009$$gVol. 53, p. 1346 - 1358$$p1346 - 1358$$q53<1346 - 1358$$tNeuroImage$$v53$$x1053-8119$$y2010
000011234 8567_ $$uhttp://dx.doi.org/10.1016/j.neuroimage.2010.07.009
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