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000011284 084__ $$2WoS$$aBiochemistry & Molecular Biology
000011284 084__ $$2WoS$$aBiology
000011284 1001_ $$0P:(DE-Juel1)131631$$aAmunts, K.$$b0$$uFZJ
000011284 245__ $$aBroca's Region: Novel Organizational Principles and Multiple Receptor Mapping
000011284 260__ $$aLawrence, KS$$bPLoS$$c2010
000011284 300__ $$ae1000489
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000011284 440_0 $$014044$$aPLoS Biology$$v8$$x1544-9173$$y9
000011284 500__ $$aThis work was supported by the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (AF), the Bundesministerium fur Bildung und Forschung (01GW0771, 01GW0623; KA), and the Deutsche Forschungsgemeinschaft (AM 118/1-2). The study was partially supported by the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (KZ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
000011284 520__ $$aThere is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.
000011284 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000011284 536__ $$0G:(DE-Juel1)BMBF-01GW0771$$aBMBF-01GW0771 - Neuroanatomische Kartierung des frontalen Operculums (BMBF-01GW0771)$$cBMBF-01GW0771$$fNeuroanatomische Kartierung des frontalen Operculums$$x1
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000011284 650_2 $$2MeSH$$aAnimals
000011284 650_2 $$2MeSH$$aAutoradiography
000011284 650_2 $$2MeSH$$aFrontal Lobe: metabolism
000011284 650_2 $$2MeSH$$aHumans
000011284 650_2 $$2MeSH$$aReceptors, Cell Surface: metabolism
000011284 650_7 $$00$$2NLM Chemicals$$aReceptors, Cell Surface
000011284 650_7 $$2WoSType$$aJ
000011284 7001_ $$0P:(DE-Juel1)VDB94440$$aLenzen, M.$$b1$$uFZJ
000011284 7001_ $$0P:(DE-HGF)0$$aFriederici, A.D.$$b2
000011284 7001_ $$0P:(DE-HGF)0$$aSchleicher, A.$$b3
000011284 7001_ $$0P:(DE-Juel1)VDB1090$$aMorosan, P.$$b4$$uFZJ
000011284 7001_ $$0P:(DE-Juel1)VDB1208$$aPalomero-Gallagher, N.$$b5$$uFZJ
000011284 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b6$$uFZJ
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000011284 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943440
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