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@ARTICLE{Amunts:11284,
      author       = {Amunts, K. and Lenzen, M. and Friederici, A.D. and
                      Schleicher, A. and Morosan, P. and Palomero-Gallagher, N.
                      and Zilles, K.},
      title        = {{B}roca's {R}egion: {N}ovel {O}rganizational {P}rinciples
                      and {M}ultiple {R}eceptor {M}apping},
      journal      = {PLoS biology},
      volume       = {8},
      issn         = {1544-9173},
      address      = {Lawrence, KS},
      publisher    = {PLoS},
      reportid     = {PreJuSER-11284},
      pages        = {e1000489},
      year         = {2010},
      note         = {This work was supported by the Max Planck Institute for
                      Human Cognitive and Brain Sciences, Leipzig, Germany (AF),
                      the Bundesministerium fur Bildung und Forschung (01GW0771,
                      01GW0623; KA), and the Deutsche Forschungsgemeinschaft (AM
                      118/1-2). The study was partially supported by the
                      Initiative and Networking Fund of the Helmholtz Association
                      within the Helmholtz Alliance on Systems Biology (KZ). The
                      funders had no role in study design, data collection and
                      analysis, decision to publish, or preparation of the
                      manuscript.},
      abstract     = {There is a considerable contrast between the various
                      functions assigned to Broca's region and its relatively
                      simple subdivision into two cytoarchitectonic areas (44 and
                      45). Since the regional distribution of transmitter
                      receptors in the cerebral cortex has been proven a powerful
                      indicator of functional diversity, the subdivision of
                      Broca's region was analyzed here using a multireceptor
                      approach. The distribution patterns of six receptor types
                      using in vitro receptor autoradiography revealed previously
                      unknown areas: a ventral precentral transitional cortex 6r1,
                      dorsal and ventral areas 44d and 44v, anterior and posterior
                      areas 45a and 45p, and areas op8 and op9 in the frontal
                      operculum. A significant lateralization of receptors was
                      demonstrated with respect to the cholinergic M(2) receptor,
                      particularly in area 44v+d. We propose a new concept of the
                      anterior language region, which elucidates the relation
                      between premotor cortex, prefrontal cortex, and Broca's
                      region. It offers human brain homologues to the recently
                      described subdivision of area 45, and the segregation of the
                      ventral premotor cortex in macaque brains. The results
                      provide a novel structural basis of the organization of
                      language regions in the brain.},
      keywords     = {Animals / Autoradiography / Frontal Lobe: metabolism /
                      Humans / Receptors, Cell Surface: metabolism / Receptors,
                      Cell Surface (NLM Chemicals) / J (WoSType)},
      cin          = {INM-2 / INM-1 / JARA-BRAIN},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      BMBF-01GW0771 - Neuroanatomische Kartierung des frontalen
                      Operculums (BMBF-01GW0771) / BMBF-01GW0623 - Anatomische
                      Basis von Prosodie und Gesang (BMBF-01GW0623) / 89571 -
                      Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)BMBF-01GW0771 /
                      G:(DE-Juel1)BMBF-01GW0623 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20877713},
      pmc          = {pmc:PMC2943440},
      UT           = {WOS:000282279200009},
      doi          = {10.1371/journal.pbio.1000489},
      url          = {https://juser.fz-juelich.de/record/11284},
}