Hauptseite > Publikationsdatenbank > Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping > print

001     11284
005     20210129210540.0
024 7 _ |2 pmid
|a pmid:20877713
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|a pmc:PMC2943440
024 7 _ |2 DOI
|a 10.1371/journal.pbio.1000489
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037 _ _ |a PreJuSER-11284
041 _ _ |a eng
082 _ _ |a 500
084 _ _ |2 WoS
|a Biochemistry & Molecular Biology
084 _ _ |2 WoS
|a Biology
100 1 _ |0 P:(DE-Juel1)131631
|a Amunts, K.
|b 0
|u FZJ
245 _ _ |a Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
260 _ _ |a Lawrence, KS
|b PLoS
|c 2010
300 _ _ |a e1000489
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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|2 EndNote
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a article
|2 DRIVER
440 _ 0 |0 14044
|a PLoS Biology
|v 8
|x 1544-9173
|y 9
500 _ _ |a This work was supported by the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (AF), the Bundesministerium fur Bildung und Forschung (01GW0771, 01GW0623; KA), and the Deutsche Forschungsgemeinschaft (AM 118/1-2). The study was partially supported by the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (KZ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
520 _ _ |a There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.
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|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |a BMBF-01GW0771 - Neuroanatomische Kartierung des frontalen Operculums (BMBF-01GW0771)
|0 G:(DE-Juel1)BMBF-01GW0771
|c BMBF-01GW0771
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|f Neuroanatomische Kartierung des frontalen Operculums
536 _ _ |a BMBF-01GW0623 - Anatomische Basis von Prosodie und Gesang (BMBF-01GW0623)
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|f Anatomische Basis von Prosodie und Gesang
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Autoradiography
650 _ 2 |2 MeSH
|a Frontal Lobe: metabolism
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Receptors, Cell Surface: metabolism
650 _ 7 |0 0
|2 NLM Chemicals
|a Receptors, Cell Surface
650 _ 7 |2 WoSType
|a J
700 1 _ |0 P:(DE-Juel1)VDB94440
|a Lenzen, M.
|b 1
|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Friederici, A.D.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Schleicher, A.
|b 3
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|a Morosan, P.
|b 4
|u FZJ
700 1 _ |0 P:(DE-Juel1)VDB1208
|a Palomero-Gallagher, N.
|b 5
|u FZJ
700 1 _ |0 P:(DE-Juel1)131714
|a Zilles, K.
|b 6
|u FZJ
773 _ _ |0 PERI:(DE-600)2126773-X
|a 10.1371/journal.pbio.1000489
|g Vol. 8, p. e1000489
|p e1000489
|q 8|t PLoS biology
|v 8
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|y 2010
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943440
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