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000011318 0247_ $$2DOI$$a10.1016/j.talanta.2010.07.065
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000011318 041__ $$aeng
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000011318 084__ $$2WoS$$aChemistry, Analytical
000011318 1001_ $$0P:(DE-HGF)0$$aDressler, V.L.$$b0
000011318 245__ $$aBiomonitoring of essential and toxic metals in single hair using on-line solution-based calibration in laser ablation inductively coupled plasma mass spectrometry
000011318 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2010
000011318 300__ $$a1770 - 1777
000011318 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011318 440_0 $$09621$$aTalanta$$v82$$x0039-9140$$y5
000011318 500__ $$aDirce Pozebon would like to thank CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) for financial support. The authors thank Jurgen Srega and Meike Hamester (Thermo Fisher Scientific) for instrumental support of the new BrainMet (BrainMet-Bioimaging of Metals and Metallomics) laboratory at Research Centre Juelich (www.brainmet.com).
000011318 520__ $$aLaser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been established as a powerful and sensitive surface analytical technique for the determination of concentration and distribution of trace metals within biological systems at micrometer spatial resolution. LA-ICP-MS allows easy quantification procedures if suitable standard references materials (SRM) are available. In this work a new SRM-free approach of solution-based calibration method in LA-ICP-MS for element quantification in hair is described. A dual argon flow of the carrier gas and nebulizer gas is used. A dry aerosol produced by laser ablation (LA) of biological sample and a desolvated aerosol generated by pneumatic nebulization (PN) of standard solutions are carried by two different flows of argon as carrier or nebulizer gas, respectively and introduced separately in the injector tube of a special ICP torch, through two separated apertures. Both argon flows are mixed directly in the ICP torch. External calibration via defined standard solutions before analysis of single hair was employed as calibration strategy. A correction factor, calculated using hair with known analyte concentration (measured by ICP-MS), is applied to correct the different elemental sensitivities of ICP-MS and LA-ICP-MS. Calibration curves are obtained by plotting the ratio of analyte ion M(+)/(34)S(+) ion intensities measured using LA-ICP-MS in dependence of analyte concentration in calibration solutions. Matrix-matched on-line calibration in LA-ICP-MS is carried out by ablating of human hair strands (mounted on a sticky tape in the LA chamber) using a focused laser beam in parallel with conventional nebulization of calibration solutions. Calibrations curves of Li, Na, Mg, Al, K, V, Cr, Mn, Fe, Ni, Co, Cu, Zn, Sr, Mo, Ag, Cd, I, Hg, Pb, Tl, Bi and U are presented. The linear correlation coefficients (R) of calibration curves for analytes were typically between 0.97 and 0.999. The limits of detection (LODs) of Li, V, Mn, Ni, Co, Cu, Sr, Mo, Ag, Ba, Cd, I, Hg, Pb, Bi and U in a single hair strand were in the range of 0.001-0.90 μg g(-1), whereas those of Cr and Zn were 3.4 and 5.1 μg g(-1), respectively. The proposed quantification strategy using on-line solution-based calibration in LA-ICP-MS was applied for biomonitoring (the spatial resolved distribution analysis) of essential and toxic metals and iodine in human hair and mouse hair.
000011318 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000011318 536__ $$0G:(DE-HGF)POF2-89573$$a89573 - Neuroimaging (POF2-89573)$$cPOF2-89573$$fPOF II T$$x1
000011318 588__ $$aDataset connected to Web of Science, Pubmed
000011318 650_2 $$2MeSH$$aAnimals
000011318 650_2 $$2MeSH$$aCalibration
000011318 650_2 $$2MeSH$$aEnvironmental Monitoring: instrumentation
000011318 650_2 $$2MeSH$$aEnvironmental Monitoring: methods
000011318 650_2 $$2MeSH$$aHair: chemistry
000011318 650_2 $$2MeSH$$aHumans
000011318 650_2 $$2MeSH$$aIodine: analysis
000011318 650_2 $$2MeSH$$aLasers
000011318 650_2 $$2MeSH$$aLimit of Detection
000011318 650_2 $$2MeSH$$aMetals, Heavy: analysis
000011318 650_2 $$2MeSH$$aMetals, Heavy: toxicity
000011318 650_2 $$2MeSH$$aMice
000011318 650_2 $$2MeSH$$aReference Standards
000011318 650_2 $$2MeSH$$aSolutions
000011318 650_2 $$2MeSH$$aSpectrophotometry, Atomic: methods
000011318 650_2 $$2MeSH$$aSpectrophotometry, Atomic: standards
000011318 650_2 $$2MeSH$$aTrace Elements: analysis
000011318 650_2 $$2MeSH$$aTrace Elements: toxicity
000011318 650_7 $$00$$2NLM Chemicals$$aMetals, Heavy
000011318 650_7 $$00$$2NLM Chemicals$$aSolutions
000011318 650_7 $$00$$2NLM Chemicals$$aTrace Elements
000011318 650_7 $$07553-56-2$$2NLM Chemicals$$aIodine
000011318 650_7 $$2WoSType$$aJ
000011318 65320 $$2Author$$aBiomonitoring
000011318 65320 $$2Author$$aLA-ICP-MS
000011318 65320 $$2Author$$aHair
000011318 65320 $$2Author$$aMetals
000011318 65320 $$2Author$$aSolution-based calibration
000011318 7001_ $$0P:(DE-HGF)0$$aPozebon, D.$$b1
000011318 7001_ $$0P:(DE-HGF)0$$aFoster Mesko, M.$$b2
000011318 7001_ $$0P:(DE-Juel1)138474$$aMatusch, A.$$b3$$uFZJ
000011318 7001_ $$0P:(DE-Juel1)VDB92998$$aKumtabtim, U.$$b4$$uFZJ
000011318 7001_ $$0P:(DE-Juel1)138881$$aWu, B.$$b5$$uFZJ
000011318 7001_ $$0P:(DE-Juel1)VDB2662$$aBecker, J. S.$$b6$$uFZJ
000011318 773__ $$0PERI:(DE-600)1500969-5$$a10.1016/j.talanta.2010.07.065$$gVol. 82, p. 1770 - 1777$$p1770 - 1777$$q82<1770 - 1777$$tTalanta$$v82$$x0039-9140$$y2010
000011318 8567_ $$uhttp://dx.doi.org/10.1016/j.talanta.2010.07.065
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