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@ARTICLE{Dressler:11318,
      author       = {Dressler, V.L. and Pozebon, D. and Foster Mesko, M. and
                      Matusch, A. and Kumtabtim, U. and Wu, B. and Becker, J. S.},
      title        = {{B}iomonitoring of essential and toxic metals in single
                      hair using on-line solution-based calibration in laser
                      ablation inductively coupled plasma mass spectrometry},
      journal      = {Talanta},
      volume       = {82},
      issn         = {0039-9140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-11318},
      pages        = {1770 - 1777},
      year         = {2010},
      note         = {Dirce Pozebon would like to thank CAPES (Coordenacao de
                      Aperfeicoamento de Pessoal de Nivel Superior) for financial
                      support. The authors thank Jurgen Srega and Meike Hamester
                      (Thermo Fisher Scientific) for instrumental support of the
                      new BrainMet (BrainMet-Bioimaging of Metals and Metallomics)
                      laboratory at Research Centre Juelich (www.brainmet.com).},
      abstract     = {Laser ablation inductively coupled plasma mass spectrometry
                      (LA-ICP-MS) has been established as a powerful and sensitive
                      surface analytical technique for the determination of
                      concentration and distribution of trace metals within
                      biological systems at micrometer spatial resolution.
                      LA-ICP-MS allows easy quantification procedures if suitable
                      standard references materials (SRM) are available. In this
                      work a new SRM-free approach of solution-based calibration
                      method in LA-ICP-MS for element quantification in hair is
                      described. A dual argon flow of the carrier gas and
                      nebulizer gas is used. A dry aerosol produced by laser
                      ablation (LA) of biological sample and a desolvated aerosol
                      generated by pneumatic nebulization (PN) of standard
                      solutions are carried by two different flows of argon as
                      carrier or nebulizer gas, respectively and introduced
                      separately in the injector tube of a special ICP torch,
                      through two separated apertures. Both argon flows are mixed
                      directly in the ICP torch. External calibration via defined
                      standard solutions before analysis of single hair was
                      employed as calibration strategy. A correction factor,
                      calculated using hair with known analyte concentration
                      (measured by ICP-MS), is applied to correct the different
                      elemental sensitivities of ICP-MS and LA-ICP-MS. Calibration
                      curves are obtained by plotting the ratio of analyte ion
                      M(+)/(34)S(+) ion intensities measured using LA-ICP-MS in
                      dependence of analyte concentration in calibration
                      solutions. Matrix-matched on-line calibration in LA-ICP-MS
                      is carried out by ablating of human hair strands (mounted on
                      a sticky tape in the LA chamber) using a focused laser beam
                      in parallel with conventional nebulization of calibration
                      solutions. Calibrations curves of Li, Na, Mg, Al, K, V, Cr,
                      Mn, Fe, Ni, Co, Cu, Zn, Sr, Mo, Ag, Cd, I, Hg, Pb, Tl, Bi
                      and U are presented. The linear correlation coefficients (R)
                      of calibration curves for analytes were typically between
                      0.97 and 0.999. The limits of detection (LODs) of Li, V, Mn,
                      Ni, Co, Cu, Sr, Mo, Ag, Ba, Cd, I, Hg, Pb, Bi and U in a
                      single hair strand were in the range of 0.001-0.90 μg
                      g(-1), whereas those of Cr and Zn were 3.4 and 5.1 μg
                      g(-1), respectively. The proposed quantification strategy
                      using on-line solution-based calibration in LA-ICP-MS was
                      applied for biomonitoring (the spatial resolved distribution
                      analysis) of essential and toxic metals and iodine in human
                      hair and mouse hair.},
      keywords     = {Animals / Calibration / Environmental Monitoring:
                      instrumentation / Environmental Monitoring: methods / Hair:
                      chemistry / Humans / Iodine: analysis / Lasers / Limit of
                      Detection / Metals, Heavy: analysis / Metals, Heavy:
                      toxicity / Mice / Reference Standards / Solutions /
                      Spectrophotometry, Atomic: methods / Spectrophotometry,
                      Atomic: standards / Trace Elements: analysis / Trace
                      Elements: toxicity / Metals, Heavy (NLM Chemicals) /
                      Solutions (NLM Chemicals) / Trace Elements (NLM Chemicals) /
                      Iodine (NLM Chemicals) / J (WoSType)},
      cin          = {INM-4 / ZCH / INM-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)ZCH-20090406 /
                      I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89573 - Neuroimaging (POF2-89573)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89573},
      shelfmark    = {Chemistry, Analytical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20875575},
      UT           = {WOS:000283903300021},
      doi          = {10.1016/j.talanta.2010.07.065},
      url          = {https://juser.fz-juelich.de/record/11318},
}