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000011385 0247_ $$2pmid$$apmid:20879808
000011385 0247_ $$2DOI$$a10.3109/15622975.2010.518624
000011385 0247_ $$2WOS$$aWOS:000290405200004
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000011385 041__ $$aeng
000011385 082__ $$a610
000011385 084__ $$2WoS$$aPsychiatry
000011385 1001_ $$0P:(DE-HGF)0$$aAhrendts, J.$$b0
000011385 245__ $$aVisual cortex abnormalities in adults with ADHD: A structural MRI study
000011385 260__ $$aLondon [u.a.]$$bInforma Healthcare$$c2011
000011385 300__ $$a260 - 270
000011385 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011385 3367_ $$2BibTeX$$aARTICLE
000011385 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000011385 3367_ $$2DRIVER$$aarticle
000011385 440_0 $$023962$$aWorld Journal of Biological Psychiatry$$v12$$x1562-2975$$y4
000011385 500__ $$aThis work was supported by grants from the German Federal Ministry of Education and Research (# 01GV0606 to LTVE), and the Ministry of Science, Research and the Arts of Baden-Wurttemberg, Germany (AZ: 23-7532.22-11/1 to LTVE). NR was supported by a Marie Curie Outgoing International Fellowship of the European Union. MW received funding from the German Research Council (DFG: SFB550, C4). The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
000011385 520__ $$aMost structural imaging studies in ADHD have focused on prefronto-striatal circuits. However, findings remained inconsistent while recent reports point to the posterior parietal cortex as an additional target for research. Moreover, although adult ADHD clinically differs from the childhood presentation little is known about the structural correlates of ADHD in adults. The aim of this study was to clarify the involvement of prefronto-striatal and posterior parietal areas in adult ADHD.Voxel-based morphometry of high resolution MRI scans was applied to analyze volumetric brain differences between 31 adult patients with ADHD and 31 control subjects.The volume of prefrontal, striatal and parietal gray matter was normal. ADHD patients displayed a significant reduction of gray matter volume bilaterally in the early visual cortex (P<0.04).The unexpected finding of visual cortex abnormalities might be related to impairments in early-stage, 'subexecutive" attentional mechanisms. The results support the notion that executive dysfunction may not be the dominant neurobiological characteristic of ADHD at least in adult patients. The visual cortex deserves more consideration as a potentially important site of dysfunction in adult and possibly childhood ADHD.
000011385 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000011385 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000011385 588__ $$aDataset connected to Web of Science, Pubmed
000011385 650_2 $$2MeSH$$aAdolescent
000011385 650_2 $$2MeSH$$aAdult
000011385 650_2 $$2MeSH$$aAnalysis of Variance
000011385 650_2 $$2MeSH$$aArtifacts
000011385 650_2 $$2MeSH$$aAttention Deficit Disorder with Hyperactivity: pathology
000011385 650_2 $$2MeSH$$aBrain Mapping: methods
000011385 650_2 $$2MeSH$$aFemale
000011385 650_2 $$2MeSH$$aHumans
000011385 650_2 $$2MeSH$$aImage Processing, Computer-Assisted: methods
000011385 650_2 $$2MeSH$$aImaging, Three-Dimensional: methods
000011385 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000011385 650_2 $$2MeSH$$aMale
000011385 650_2 $$2MeSH$$aMiddle Aged
000011385 650_2 $$2MeSH$$aVisual Cortex: abnormalities
000011385 650_2 $$2MeSH$$aVisual Cortex: pathology
000011385 650_2 $$2MeSH$$aYoung Adult
000011385 650_7 $$2WoSType$$aJ
000011385 7001_ $$0P:(DE-HGF)0$$aRüsch, N.$$b1
000011385 7001_ $$0P:(DE-HGF)0$$aWilke, M.$$b2
000011385 7001_ $$0P:(DE-HGF)0$$aPhilipsen, A.$$b3
000011385 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b4$$uFZJ
000011385 7001_ $$0P:(DE-HGF)0$$aGlauche, V.$$b5
000011385 7001_ $$0P:(DE-HGF)0$$aPerlov, E.$$b6
000011385 7001_ $$0P:(DE-HGF)0$$aEbert, D.$$b7
000011385 7001_ $$0P:(DE-HGF)0$$aHennig, J.$$b8
000011385 7001_ $$0P:(DE-HGF)0$$aTebartz van Elst, L.$$b9
000011385 773__ $$0PERI:(DE-600)2170223-8$$a10.3109/15622975.2010.518624$$gVol. 12, p. 260 - 270$$p260 - 270$$q12<260 - 270$$tThe @world journal of biological psychiatry$$v12$$x1562-2975$$y2011
000011385 8567_ $$uhttp://dx.doi.org/10.3109/15622975.2010.518624
000011385 909CO $$ooai:juser.fz-juelich.de:11385$$pVDB
000011385 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000011385 915__ $$0StatID:(DE-HGF)0020$$aNo peer review
000011385 9141_ $$y2011
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