TY  - JOUR
AU  - Ahrendts, J.
AU  - Rüsch, N.
AU  - Wilke, M.
AU  - Philipsen, A.
AU  - Eickhoff, S. B.
AU  - Glauche, V.
AU  - Perlov, E.
AU  - Ebert, D.
AU  - Hennig, J.
AU  - Tebartz van Elst, L.
TI  - Visual cortex abnormalities in adults with ADHD: A structural MRI study
JO  - The world journal of biological psychiatry
VL  - 12
SN  - 1562-2975
CY  - London [u.a.]
PB  - Informa Healthcare
M1  - PreJuSER-11385
SP  - 260 - 270
PY  - 2011
N1  - This work was supported by grants from the German Federal Ministry of Education and Research (# 01GV0606 to LTVE), and the Ministry of Science, Research and the Arts of Baden-Wurttemberg, Germany (AZ: 23-7532.22-11/1 to LTVE). NR was supported by a Marie Curie Outgoing International Fellowship of the European Union. MW received funding from the German Research Council (DFG: SFB550, C4). The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
AB  - Most structural imaging studies in ADHD have focused on prefronto-striatal circuits. However, findings remained inconsistent while recent reports point to the posterior parietal cortex as an additional target for research. Moreover, although adult ADHD clinically differs from the childhood presentation little is known about the structural correlates of ADHD in adults. The aim of this study was to clarify the involvement of prefronto-striatal and posterior parietal areas in adult ADHD.Voxel-based morphometry of high resolution MRI scans was applied to analyze volumetric brain differences between 31 adult patients with ADHD and 31 control subjects.The volume of prefrontal, striatal and parietal gray matter was normal. ADHD patients displayed a significant reduction of gray matter volume bilaterally in the early visual cortex (P<0.04).The unexpected finding of visual cortex abnormalities might be related to impairments in early-stage, 'subexecutive" attentional mechanisms. The results support the notion that executive dysfunction may not be the dominant neurobiological characteristic of ADHD at least in adult patients. The visual cortex deserves more consideration as a potentially important site of dysfunction in adult and possibly childhood ADHD.
KW  - Adolescent
KW  - Adult
KW  - Analysis of Variance
KW  - Artifacts
KW  - Attention Deficit Disorder with Hyperactivity: pathology
KW  - Brain Mapping: methods
KW  - Female
KW  - Humans
KW  - Image Processing, Computer-Assisted: methods
KW  - Imaging, Three-Dimensional: methods
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Middle Aged
KW  - Visual Cortex: abnormalities
KW  - Visual Cortex: pathology
KW  - Young Adult
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20879808
UR  - <Go to ISI:>//WOS:000290405200004
DO  - DOI:10.3109/15622975.2010.518624
UR  - https://juser.fz-juelich.de/record/11385
ER  -