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@ARTICLE{Ahrendts:11385,
      author       = {Ahrendts, J. and Rüsch, N. and Wilke, M. and Philipsen, A.
                      and Eickhoff, S. B. and Glauche, V. and Perlov, E. and
                      Ebert, D. and Hennig, J. and Tebartz van Elst, L.},
      title        = {{V}isual cortex abnormalities in adults with {ADHD}: {A}
                      structural {MRI} study},
      journal      = {The world journal of biological psychiatry},
      volume       = {12},
      issn         = {1562-2975},
      address      = {London [u.a.]},
      publisher    = {Informa Healthcare},
      reportid     = {PreJuSER-11385},
      pages        = {260 - 270},
      year         = {2011},
      note         = {This work was supported by grants from the German Federal
                      Ministry of Education and Research (# 01GV0606 to LTVE), and
                      the Ministry of Science, Research and the Arts of
                      Baden-Wurttemberg, Germany (AZ: 23-7532.22-11/1 to LTVE). NR
                      was supported by a Marie Curie Outgoing International
                      Fellowship of the European Union. MW received funding from
                      the German Research Council (DFG: SFB550, C4). The funding
                      sources had no further role in study design; in the
                      collection, analysis and interpretation of data; in the
                      writing of the report; and in the decision to submit the
                      paper for publication.},
      abstract     = {Most structural imaging studies in ADHD have focused on
                      prefronto-striatal circuits. However, findings remained
                      inconsistent while recent reports point to the posterior
                      parietal cortex as an additional target for research.
                      Moreover, although adult ADHD clinically differs from the
                      childhood presentation little is known about the structural
                      correlates of ADHD in adults. The aim of this study was to
                      clarify the involvement of prefronto-striatal and posterior
                      parietal areas in adult ADHD.Voxel-based morphometry of high
                      resolution MRI scans was applied to analyze volumetric brain
                      differences between 31 adult patients with ADHD and 31
                      control subjects.The volume of prefrontal, striatal and
                      parietal gray matter was normal. ADHD patients displayed a
                      significant reduction of gray matter volume bilaterally in
                      the early visual cortex (P<0.04).The unexpected finding of
                      visual cortex abnormalities might be related to impairments
                      in early-stage, 'subexecutive" attentional mechanisms. The
                      results support the notion that executive dysfunction may
                      not be the dominant neurobiological characteristic of ADHD
                      at least in adult patients. The visual cortex deserves more
                      consideration as a potentially important site of dysfunction
                      in adult and possibly childhood ADHD.},
      keywords     = {Adolescent / Adult / Analysis of Variance / Artifacts /
                      Attention Deficit Disorder with Hyperactivity: pathology /
                      Brain Mapping: methods / Female / Humans / Image Processing,
                      Computer-Assisted: methods / Imaging, Three-Dimensional:
                      methods / Magnetic Resonance Imaging: methods / Male /
                      Middle Aged / Visual Cortex: abnormalities / Visual Cortex:
                      pathology / Young Adult / J (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20879808},
      UT           = {WOS:000290405200004},
      doi          = {10.3109/15622975.2010.518624},
      url          = {https://juser.fz-juelich.de/record/11385},
}