%0 Journal Article
%A Bittkau, K.
%A Schulte, M.
%A Beckers, T.
%A Carius, R.
%T Fourier analysis for the study of light scattering properties of randomly textured ZnO films
%J SPIE newsroom
%V 7725
%@ 1818-2259
%M PreJuSER-11454
%P 77250N
%D 2010
%Z Record converted from VDB: 12.11.2012
%X As liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
%K Adult
%K Female
%K Hepatitis B, Chronic: complications
%K Humans
%K Interleukin 1 Receptor Antagonist Protein: genetics
%K Interleukin-10: genetics
%K Interleukin-1beta: genetics
%K Liver Cirrhosis: complications
%K Liver Cirrhosis: genetics
%K Male
%K Polymorphism, Genetic
%K Tumor Necrosis Factor-alpha: genetics
%K IL1RN protein, human (NLM Chemicals)
%K Interleukin 1 Receptor Antagonist Protein (NLM Chemicals)
%K Interleukin-1beta (NLM Chemicals)
%K Tumor Necrosis Factor-alpha (NLM Chemicals)
%K Interleukin-10 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:17645476
%U <Go to ISI:>//WOS:000285288500017
%R 10.1117/12.854337
%U https://juser.fz-juelich.de/record/11454