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000011454 0247_ $$2pmid$$apmid:17645476
000011454 0247_ $$2DOI$$a10.1117/12.854337
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000011454 041__ $$aeng
000011454 1001_ $$0P:(DE-Juel1)130219$$aBittkau, K.$$b0$$uFZJ
000011454 245__ $$aFourier analysis for the study of light scattering properties of randomly textured ZnO films
000011454 260__ $$c2010
000011454 300__ $$a77250N
000011454 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011454 520__ $$aAs liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
000011454 536__ $$0G:(DE-Juel1)FUEK401$$2G:(DE-HGF)$$aErneuerbare Energien$$cP11$$x0
000011454 588__ $$aDataset connected to Pubmed
000011454 650_2 $$2MeSH$$aAdult
000011454 650_2 $$2MeSH$$aFemale
000011454 650_2 $$2MeSH$$aHepatitis B, Chronic: complications
000011454 650_2 $$2MeSH$$aHumans
000011454 650_2 $$2MeSH$$aInterleukin 1 Receptor Antagonist Protein: genetics
000011454 650_2 $$2MeSH$$aInterleukin-10: genetics
000011454 650_2 $$2MeSH$$aInterleukin-1beta: genetics
000011454 650_2 $$2MeSH$$aLiver Cirrhosis: complications
000011454 650_2 $$2MeSH$$aLiver Cirrhosis: genetics
000011454 650_2 $$2MeSH$$aMale
000011454 650_2 $$2MeSH$$aPolymorphism, Genetic
000011454 650_2 $$2MeSH$$aTumor Necrosis Factor-alpha: genetics
000011454 650_7 $$00$$2NLM Chemicals$$aIL1RN protein, human
000011454 650_7 $$00$$2NLM Chemicals$$aInterleukin 1 Receptor Antagonist Protein
000011454 650_7 $$00$$2NLM Chemicals$$aInterleukin-1beta
000011454 650_7 $$00$$2NLM Chemicals$$aTumor Necrosis Factor-alpha
000011454 650_7 $$0130068-27-8$$2NLM Chemicals$$aInterleukin-10
000011454 7001_ $$0P:(DE-Juel1)2402$$aSchulte, M.$$b1$$uFZJ
000011454 7001_ $$0P:(DE-Juel1)VDB81477$$aBeckers, T.$$b2$$uFZJ
000011454 7001_ $$0P:(DE-Juel1)VDB4964$$aCarius, R.$$b3$$uFZJ
000011454 773__ $$0PERI:(DE-600)2619543-4$$a10.1117/12.854337$$gVol. 7725, p. 77250N$$p77250N$$q7725<77250N$$tSPIE newsroom$$v7725$$x1818-2259$$y2010
000011454 8567_ $$uhttp://dx.doi.org/10.1117/12.854337
000011454 909CO $$ooai:juser.fz-juelich.de:11454$$pVDB
000011454 9141_ $$y2010
000011454 9131_ $$0G:(DE-Juel1)FUEK401$$bEnergie$$kP11$$lErneuerbare Energien$$vErneuerbare Energien$$x0
000011454 9132_ $$0G:(DE-HGF)POF3-121$$1G:(DE-HGF)POF3-120$$2G:(DE-HGF)POF3-100$$aDE-HGF$$bForschungsbereich Energie$$lErneuerbare Energien$$vSolar cells of the next generation$$x0
000011454 9201_ $$0I:(DE-Juel1)VDB813$$d30.09.2010$$gIEF$$kIEF-5$$lPhotovoltaik$$x0
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