001     11454
005     20240708133704.0
024 7 _ |2 pmid
|a pmid:17645476
024 7 _ |2 DOI
|a 10.1117/12.854337
024 7 _ |2 WOS
|a WOS:000285288500017
024 7 _ |a altmetric:21804808
|2 altmetric
037 _ _ |a PreJuSER-11454
041 _ _ |a eng
100 1 _ |0 P:(DE-Juel1)130219
|a Bittkau, K.
|b 0
|u FZJ
245 _ _ |a Fourier analysis for the study of light scattering properties of randomly textured ZnO films
260 _ _ |c 2010
300 _ _ |a 77250N
336 7 _ |0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
|a Journal Article
336 7 _ |2 DataCite
|a Output Types/Journal article
336 7 _ |0 0
|2 EndNote
|a Journal Article
336 7 _ |2 BibTeX
|a ARTICLE
336 7 _ |2 ORCID
|a JOURNAL_ARTICLE
336 7 _ |2 DRIVER
|a article
440 _ 0 |0 15562
|a SPIE Newsroom
|v 7725
|x 1818-2259
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a As liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
536 _ _ |0 G:(DE-Juel1)FUEK401
|2 G:(DE-HGF)
|a Erneuerbare Energien
|c P11
|x 0
588 _ _ |a Dataset connected to Pubmed
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Hepatitis B, Chronic: complications
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Interleukin 1 Receptor Antagonist Protein: genetics
650 _ 2 |2 MeSH
|a Interleukin-10: genetics
650 _ 2 |2 MeSH
|a Interleukin-1beta: genetics
650 _ 2 |2 MeSH
|a Liver Cirrhosis: complications
650 _ 2 |2 MeSH
|a Liver Cirrhosis: genetics
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Polymorphism, Genetic
650 _ 2 |2 MeSH
|a Tumor Necrosis Factor-alpha: genetics
650 _ 7 |0 0
|2 NLM Chemicals
|a IL1RN protein, human
650 _ 7 |0 0
|2 NLM Chemicals
|a Interleukin 1 Receptor Antagonist Protein
650 _ 7 |0 0
|2 NLM Chemicals
|a Interleukin-1beta
650 _ 7 |0 0
|2 NLM Chemicals
|a Tumor Necrosis Factor-alpha
650 _ 7 |0 130068-27-8
|2 NLM Chemicals
|a Interleukin-10
700 1 _ |0 P:(DE-Juel1)2402
|a Schulte, M.
|b 1
|u FZJ
700 1 _ |0 P:(DE-Juel1)VDB81477
|a Beckers, T.
|b 2
|u FZJ
700 1 _ |0 P:(DE-Juel1)VDB4964
|a Carius, R.
|b 3
|u FZJ
773 _ _ |0 PERI:(DE-600)2619543-4
|a 10.1117/12.854337
|g Vol. 7725, p. 77250N
|p 77250N
|q 7725<77250N
|t SPIE newsroom
|v 7725
|x 1818-2259
|y 2010
856 7 _ |u http://dx.doi.org/10.1117/12.854337
909 C O |o oai:juser.fz-juelich.de:11454
|p VDB
913 1 _ |0 G:(DE-Juel1)FUEK401
|b Energie
|k P11
|l Erneuerbare Energien
|v Erneuerbare Energien
|x 0
913 2 _ |0 G:(DE-HGF)POF3-121
|1 G:(DE-HGF)POF3-120
|2 G:(DE-HGF)POF3-100
|a DE-HGF
|b Forschungsbereich Energie
|l Erneuerbare Energien
|v Solar cells of the next generation
|x 0
914 1 _ |y 2010
920 1 _ |0 I:(DE-Juel1)VDB813
|d 30.09.2010
|g IEF
|k IEF-5
|l Photovoltaik
|x 0
970 _ _ |a VDB:(DE-Juel1)122576
980 _ _ |a VDB
980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)IEK-5-20101013
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IMD-3-20101013
981 _ _ |a I:(DE-Juel1)IEK-5-20101013


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