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@ARTICLE{dErrico:11530,
      author       = {d'Errico, G. and Silipo, A. and Mangiapia, G. and Vitiello,
                      G. and Radulescu, A. and Molinaro, A. and Lanzetta, R. and
                      Paduano, L.},
      title        = {{C}haracterization of {L}iposomes {F}ormed by
                      {L}ipopolysaccharides from {B}urkholderia {C}enocepacia,
                      {B}urkholderia {M}ultivorans und {A}grobacterium
                      {T}umefaciens: from the {M}olecular {S}tructure to the
                      {A}ggregate {A}rchitecture},
      journal      = {Physical Chemistry Chemical Physics},
      volume       = {12},
      issn         = {1463-9076},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {PreJuSER-11530},
      pages        = {13574 - 13585},
      year         = {2010},
      note         = {The authors thank CSGI (Consorzio Interuniversitario per lo
                      sviluppo dei Sistemi a Grande Interfase) and MIUR (PRIN
                      2007) for financial support. B. multivorans cells were
                      kindly furnished by Dr Paola Cescutti (Universita di
                      Trieste), B. cenocepacia cells were kindly furnished by Dr
                      Anthony De-Soyza (University of Newcastle) and R-LPS from A.
                      tumefaciens was a kind gift from Dr Cristina De Castro
                      (Universita di Napoli). Forschungszentrum Julich is
                      acknowledged for provision of beam time. SANS experiments
                      were supported by the European Commission, NMI3 contract
                      RII3-CT-2003-505925. The authors thank Prof. Lucia
                      Costantino for her helpful comments. Finally, we thank the
                      referees whose comments helped improve the manuscript.},
      abstract     = {The microstructure of liposomes formed by the
                      lipopolysaccharides (LPS) derived from Burkholderia
                      cenocepacia ET-12 type strain LMG 16656, Burkholderia
                      multivorans strain C1576 and Agrobacterium tumefaciens
                      strain TT111 has been investigated by a combined
                      experimental strategy, including dynamic light scattering
                      (DLS), small-angle neutron scattering (SANS) and electron
                      paramagnetic resonance (EPR). The results highlight that the
                      LPS molecular structure determines, through a complex
                      interplay of hydrophobic, steric and electrostatic
                      interactions, the morphology of the aggregates formed in
                      aqueous medium. All the considered LPS form liposomes that
                      in most cases present a multilamellar arrangement. The
                      thickness of the hydrophobic domain of each bilayer and the
                      local ordering of the acyl chains are determined not only by
                      the molecular structure of the LPS glycolipid portion (lipid
                      A), but also, indirectly, by the bulkiness of the
                      saccharidic portion. In the case of a long polysaccharidic
                      chain, such as that of the LPS derived from Burkholderia
                      multivorans, liposomes coexist with elongated micellar
                      aggregates, whose population decreases if a typical
                      phospholipid, such as dioleoyl phosphatidylethanolamine
                      (DOPE) is introduced in the liposome formulation. The effect
                      of temperature has also been considered: for all the
                      considered LPS an extremely smooth transition of the acyl
                      chain self-organization from a gel to a liquid crystalline
                      phase is detected around 30-35 °C. In the biological
                      context, our results suggest that the rich biodiversity of
                      LPS molecular structure could be fundamental to finely tune
                      the structure and functional properties of the outer
                      membrane of Gram negative bacteria.},
      keywords     = {Agrobacterium tumefaciens: metabolism / Burkholderia:
                      metabolism / Burkholderia cenocepacia: metabolism / Electron
                      Spin Resonance Spectroscopy / Light / Lipopolysaccharides:
                      chemistry / Liposomes: chemistry / Neutron Diffraction /
                      Phosphatidylethanolamines: chemistry / Scattering, Radiation
                      / Scattering, Small Angle /
                      1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine (NLM
                      Chemicals) / Lipopolysaccharides (NLM Chemicals) / Liposomes
                      (NLM Chemicals) / Phosphatidylethanolamines (NLM Chemicals)
                      / J (WoSType)},
      cin          = {IFF-4 / IFF-5 / Jülich Centre for Neutron Science JCNS
                      (JCNS) ; JCNS},
      ddc          = {540},
      cid          = {I:(DE-Juel1)VDB784 / I:(DE-Juel1)VDB785 /
                      I:(DE-Juel1)JCNS-20121112},
      pnm          = {Großgeräte für die Forschung mit Photonen, Neutronen und
                      Ionen (PNI) / BioSoft: Makromolekulare Systeme und
                      biologische Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK415 / G:(DE-Juel1)FUEK505},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      shelfmark    = {Chemistry, Physical / Physics, Atomic, Molecular $\&$
                      Chemical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20852798},
      UT           = {WOS:000282972400025},
      doi          = {10.1039/c0cp00066c},
      url          = {https://juser.fz-juelich.de/record/11530},
}