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000011587 0247_ $$2DOI$$a10.1093/cercor/bhq188
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000011587 084__ $$2WoS$$aNeurosciences
000011587 1001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b0$$uFZJ
000011587 245__ $$aNeural Correlates of Developing and Adapting Behavioral Biases in Speeded Choice Reactions - An fMRI Study on Predictive Motor Coding First published online: October 18, 2010
000011587 260__ $$aOxford$$bOxford Univ. Press$$c2011
000011587 300__ $$a1178-1191
000011587 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011587 3367_ $$2BibTeX$$aARTICLE
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000011587 440_0 $$01171$$aCerebral Cortex$$v21$$x1047-3211
000011587 500__ $$aHuman Brain Project (R01-MH074457-01A1 to S. B. E.); the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model to K.Z., S. B. E.), the Deutsche Forschungsgemeinschaft (IRTG 1328 to S. B. E.); and the Helmholtz Alliance for Mental Health in an Aging Society (HelMA to K.Z.).
000011587 520__ $$aIn reaction-time (RT) tasks with unequally probable stimuli, people respond faster and more accurately in high-probability trials than in low-probability trials. We used functional magnetic resonance imaging to investigate brain activity during the acquisition and adaptation of such biases. Participants responded to arrows pointing to either side with different and previously unknown probabilities across blocks, which were covertly reversed in the middle of some blocks. Changes in response bias were modeled using the development of the selective RT bias at the beginning of a block and after the reversal as parametric regressors. Both fresh development and reversal of an existing response bias were associated with bilateral activations in inferior parietal lobule, intraparietal sulcus, and supplementary motor cortex. Further activations were observed in right temporoparietal junction, dorsolateral prefrontal cortex, and dorsal premotor cortex. Only during initial development of biases at the beginning of a block, we observed additional activity in ventral premotor cortex and anterior insula, whereas the basal ganglia (bilaterally) were recruited when the bias was adapted to reversed probabilities. Taken together, these areas constitute a network that updates and applies implicit predictions to create an attention and motor bias according to environmental probabilities that transform into specific facilitation.
000011587 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000011587 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
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000011587 65320 $$2Author$$afunctional imaging
000011587 65320 $$2Author$$aimplicit prediction
000011587 65320 $$2Author$$apreparation
000011587 65320 $$2Author$$aprobability learning
000011587 65320 $$2Author$$aresponse bias
000011587 650_2 $$2MeSH$$aAdult
000011587 650_2 $$2MeSH$$aBias (Epidemiology)
000011587 650_2 $$2MeSH$$aBrain: physiology
000011587 650_2 $$2MeSH$$aBrain Mapping: methods
000011587 650_2 $$2MeSH$$aDecision Making: physiology
000011587 650_2 $$2MeSH$$aFemale
000011587 650_2 $$2MeSH$$aHumans
000011587 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000011587 650_2 $$2MeSH$$aMale
000011587 650_2 $$2MeSH$$aMiddle Aged
000011587 650_2 $$2MeSH$$aNerve Net: physiology
000011587 650_2 $$2MeSH$$aNeuropsychological Tests: standards
000011587 650_2 $$2MeSH$$aProbability Learning
000011587 650_2 $$2MeSH$$aReaction Time: physiology
000011587 650_2 $$2MeSH$$aYoung Adult
000011587 650_7 $$2WoSType$$aJ
000011587 7001_ $$0P:(DE-HGF)0$$aPomjanski, W.$$b1
000011587 7001_ $$0P:(DE-HGF)0$$aJakobs, O.$$b2
000011587 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b3$$uFZJ
000011587 7001_ $$0P:(DE-Juel1)131693$$aLangner, R.$$b4$$uFZJ
000011587 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhq188$$gVol. 21, p. 1178-1191$$p1178-1191$$q21<1178-1191$$tCerebral cortex$$v21$$x1047-3211$$y2011
000011587 8567_ $$uhttp://dx.doi.org/10.1093/cercor/bhq188
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000011587 9141_ $$y2011
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