TY  - JOUR
AU  - Eickhoff, S. B.
AU  - Pomjanski, W.
AU  - Jakobs, O.
AU  - Zilles, K.
AU  - Langner, R.
TI  - Neural Correlates of Developing and Adapting Behavioral Biases in Speeded Choice Reactions - An fMRI Study on Predictive Motor Coding First published online: October 18, 2010
JO  - Cerebral cortex
VL  - 21
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-11587
SP  - 1178-1191
PY  - 2011
N1  - Human Brain Project (R01-MH074457-01A1 to S. B. E.); the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model to K.Z., S. B. E.), the Deutsche Forschungsgemeinschaft (IRTG 1328 to S. B. E.); and the Helmholtz Alliance for Mental Health in an Aging Society (HelMA to K.Z.).
AB  - In reaction-time (RT) tasks with unequally probable stimuli, people respond faster and more accurately in high-probability trials than in low-probability trials. We used functional magnetic resonance imaging to investigate brain activity during the acquisition and adaptation of such biases. Participants responded to arrows pointing to either side with different and previously unknown probabilities across blocks, which were covertly reversed in the middle of some blocks. Changes in response bias were modeled using the development of the selective RT bias at the beginning of a block and after the reversal as parametric regressors. Both fresh development and reversal of an existing response bias were associated with bilateral activations in inferior parietal lobule, intraparietal sulcus, and supplementary motor cortex. Further activations were observed in right temporoparietal junction, dorsolateral prefrontal cortex, and dorsal premotor cortex. Only during initial development of biases at the beginning of a block, we observed additional activity in ventral premotor cortex and anterior insula, whereas the basal ganglia (bilaterally) were recruited when the bias was adapted to reversed probabilities. Taken together, these areas constitute a network that updates and applies implicit predictions to create an attention and motor bias according to environmental probabilities that transform into specific facilitation.
KW  - Adult
KW  - Bias (Epidemiology)
KW  - Brain: physiology
KW  - Brain Mapping: methods
KW  - Decision Making: physiology
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Middle Aged
KW  - Nerve Net: physiology
KW  - Neuropsychological Tests: standards
KW  - Probability Learning
KW  - Reaction Time: physiology
KW  - Young Adult
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20956614
UR  - <Go to ISI:>//WOS:000289578900019
DO  - DOI:10.1093/cercor/bhq188
UR  - https://juser.fz-juelich.de/record/11587
ER  -