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000011681 0247_ $$2pmid$$apmid:20074918
000011681 0247_ $$2DOI$$a10.1016/j.colsurfb.2009.12.013
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000011681 041__ $$aeng
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000011681 084__ $$2WoS$$aBiophysics
000011681 084__ $$2WoS$$aChemistry, Physical
000011681 084__ $$2WoS$$aMaterials Science, Biomaterials
000011681 1001_ $$0P:(DE-HGF)0$$aOszlánczi, A.$$b0
000011681 245__ $$aStructural and morphological changes in bacteria-membrane mimetic DPPE/DPPG/water systems induced by sulfadiazine
000011681 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2010
000011681 300__ $$a519 - 528
000011681 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011681 440_0 $$012541$$aColloids and Surfaces B: Biointerfaces$$v76$$x0927-7765$$y2
000011681 500__ $$aThis work was supported by Hungarian Scientific Funds OTKA (Bota, T 43055) and a bilateral German-Hungarian Research Project. We thank Mrs. T. Kiss for the technical assistance with freeze-fracture measurements.
000011681 520__ $$aThe effects of sulfadiazine (SD), one of the generally used antibiotics was studied on bacteria-membrane mimetic model systems consisting of pure dipalmitoylphosphatidylethanolamine (DPPE) and DPPE/dipalmitoylphosphatidylglycerol (DPPG) at 95/5, 80/20 and 50/50 DPPE/DPPG ratios by using differential scanning calorimetry (DSC), simultaneous small- and wide-angle X-ray scattering (SWAXS) and freeze-fracture technique. In the presence of SD, varied between 10-3 and 1 SD/lipid molar ratios, the 95/5 DPPE/DPPG system shows tendentious destruction in the layer arrangement which is accompanied by minor perturbations in the thermotropic behaviour. Moreover, at this lipid composition the addition of SD results in the formation of stacks of extremely extended flat bilayers. Systems having a higher DPPG molar ratio exhibit complex and diffuse morphologies. At 50/50 DPPE/DPPG ratio DPPG and SD act together and form large spherical vesicles. The uniform morphology is not accompanied by a regular lamellar arrangement. The range of the SD/lipid ratio, where the SD molecules are embedded into the lipid bilayers, extends to about 10-1. Over this limit the separation of SD molecules can be observed at all investigated DPPE/DPPG ratios.
000011681 536__ $$0G:(DE-Juel1)FUEK407$$2G:(DE-HGF)$$aTerrestrische Umwelt$$cP24$$x0
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000011681 65320 $$2Author$$aSulfadiazine
000011681 65320 $$2Author$$aDPPE/DPPG vesicles
000011681 65320 $$2Author$$aPhase separation
000011681 65320 $$2Author$$aUnbinding
000011681 65320 $$2Author$$aDSC
000011681 65320 $$2Author$$aSmall- and wide-angle X-ray scattering (SWAXS)
000011681 65320 $$2Author$$aFreeze-fracture
000011681 650_2 $$2MeSH$$aBacteria: chemistry
000011681 650_2 $$2MeSH$$aCell Membrane: chemistry
000011681 650_2 $$2MeSH$$aLipid Bilayers: chemistry
000011681 650_2 $$2MeSH$$aMolecular Structure
000011681 650_2 $$2MeSH$$aParticle Size
000011681 650_2 $$2MeSH$$aPhosphatidylethanolamines: chemistry
000011681 650_2 $$2MeSH$$aPhosphatidylglycerols: chemistry
000011681 650_2 $$2MeSH$$aSulfadiazine: chemistry
000011681 650_2 $$2MeSH$$aSurface Properties
000011681 650_2 $$2MeSH$$aTemperature
000011681 650_2 $$2MeSH$$aWater: chemistry
000011681 650_7 $$00$$2NLM Chemicals$$aLipid Bilayers
000011681 650_7 $$00$$2NLM Chemicals$$aPhosphatidylethanolamines
000011681 650_7 $$00$$2NLM Chemicals$$aPhosphatidylglycerols
000011681 650_7 $$03026-45-7$$2NLM Chemicals$$a1,2-dipalmitoyl-3-phosphatidylethanolamine
000011681 650_7 $$04537-77-3$$2NLM Chemicals$$a1,2-dipalmitoylphosphatidylglycerol
000011681 650_7 $$068-35-9$$2NLM Chemicals$$aSulfadiazine
000011681 650_7 $$07732-18-5$$2NLM Chemicals$$aWater
000011681 650_7 $$2WoSType$$aJ
000011681 7001_ $$0P:(DE-HGF)0$$aBóta, A.$$b1
000011681 7001_ $$0P:(DE-HGF)0$$aBerényi, S.$$b2
000011681 7001_ $$0P:(DE-Juel1)129484$$aKlumpp, E.$$b3$$uFZJ
000011681 773__ $$0PERI:(DE-600)1500523-9$$a10.1016/j.colsurfb.2009.12.013$$gVol. 76, p. 519 - 528$$p519 - 528$$q76<519 - 528$$tColloids and surfaces / B$$v76$$x0927-7765$$y2010
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