TY  - JOUR
AU  - Oszlánczi, A.
AU  - Bóta, A.
AU  - Berényi, S.
AU  - Klumpp, E.
TI  - Structural and morphological changes in bacteria-membrane mimetic DPPE/DPPG/water systems induced by sulfadiazine
JO  - Colloids and surfaces / B
VL  - 76
SN  - 0927-7765
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - PreJuSER-11681
SP  - 519 - 528
PY  - 2010
N1  - This work was supported by Hungarian Scientific Funds OTKA (Bota, T 43055) and a bilateral German-Hungarian Research Project. We thank Mrs. T. Kiss for the technical assistance with freeze-fracture measurements.
AB  - The effects of sulfadiazine (SD), one of the generally used antibiotics was studied on bacteria-membrane mimetic model systems consisting of pure dipalmitoylphosphatidylethanolamine (DPPE) and DPPE/dipalmitoylphosphatidylglycerol (DPPG) at 95/5, 80/20 and 50/50 DPPE/DPPG ratios by using differential scanning calorimetry (DSC), simultaneous small- and wide-angle X-ray scattering (SWAXS) and freeze-fracture technique. In the presence of SD, varied between 10-3 and 1 SD/lipid molar ratios, the 95/5 DPPE/DPPG system shows tendentious destruction in the layer arrangement which is accompanied by minor perturbations in the thermotropic behaviour. Moreover, at this lipid composition the addition of SD results in the formation of stacks of extremely extended flat bilayers. Systems having a higher DPPG molar ratio exhibit complex and diffuse morphologies. At 50/50 DPPE/DPPG ratio DPPG and SD act together and form large spherical vesicles. The uniform morphology is not accompanied by a regular lamellar arrangement. The range of the SD/lipid ratio, where the SD molecules are embedded into the lipid bilayers, extends to about 10-1. Over this limit the separation of SD molecules can be observed at all investigated DPPE/DPPG ratios.
KW  - Bacteria: chemistry
KW  - Cell Membrane: chemistry
KW  - Lipid Bilayers: chemistry
KW  - Molecular Structure
KW  - Particle Size
KW  - Phosphatidylethanolamines: chemistry
KW  - Phosphatidylglycerols: chemistry
KW  - Sulfadiazine: chemistry
KW  - Surface Properties
KW  - Temperature
KW  - Water: chemistry
KW  - Lipid Bilayers (NLM Chemicals)
KW  - Phosphatidylethanolamines (NLM Chemicals)
KW  - Phosphatidylglycerols (NLM Chemicals)
KW  - 1,2-dipalmitoyl-3-phosphatidylethanolamine (NLM Chemicals)
KW  - 1,2-dipalmitoylphosphatidylglycerol (NLM Chemicals)
KW  - Sulfadiazine (NLM Chemicals)
KW  - Water (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:20074918
UR  - <Go to ISI:>//WOS:000275352800018
DO  - DOI:10.1016/j.colsurfb.2009.12.013
UR  - https://juser.fz-juelich.de/record/11681
ER  -