Home > Publications database > Structural and morphological changes in bacteria-membrane mimetic DPPE/DPPG/water systems induced by sulfadiazine > print

001     11681
005     20180208232352.0
024 7 _ |2 pmid
|a pmid:20074918
024 7 _ |2 DOI
|a 10.1016/j.colsurfb.2009.12.013
024 7 _ |2 WOS
|a WOS:000275352800018
037 _ _ |a PreJuSER-11681
041 _ _ |a eng
082 _ _ |a 540
084 _ _ |2 WoS
|a Biophysics
084 _ _ |2 WoS
|a Chemistry, Physical
084 _ _ |2 WoS
|a Materials Science, Biomaterials
100 1 _ |0 P:(DE-HGF)0
|a Oszlánczi, A.
|b 0
245 _ _ |a Structural and morphological changes in bacteria-membrane mimetic DPPE/DPPG/water systems induced by sulfadiazine
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2010
300 _ _ |a 519 - 528
336 7 _ |a Journal Article
|0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |0 12541
|a Colloids and Surfaces B: Biointerfaces
|v 76
|x 0927-7765
|y 2
500 _ _ |a This work was supported by Hungarian Scientific Funds OTKA (Bota, T 43055) and a bilateral German-Hungarian Research Project. We thank Mrs. T. Kiss for the technical assistance with freeze-fracture measurements.
520 _ _ |a The effects of sulfadiazine (SD), one of the generally used antibiotics was studied on bacteria-membrane mimetic model systems consisting of pure dipalmitoylphosphatidylethanolamine (DPPE) and DPPE/dipalmitoylphosphatidylglycerol (DPPG) at 95/5, 80/20 and 50/50 DPPE/DPPG ratios by using differential scanning calorimetry (DSC), simultaneous small- and wide-angle X-ray scattering (SWAXS) and freeze-fracture technique. In the presence of SD, varied between 10-3 and 1 SD/lipid molar ratios, the 95/5 DPPE/DPPG system shows tendentious destruction in the layer arrangement which is accompanied by minor perturbations in the thermotropic behaviour. Moreover, at this lipid composition the addition of SD results in the formation of stacks of extremely extended flat bilayers. Systems having a higher DPPG molar ratio exhibit complex and diffuse morphologies. At 50/50 DPPE/DPPG ratio DPPG and SD act together and form large spherical vesicles. The uniform morphology is not accompanied by a regular lamellar arrangement. The range of the SD/lipid ratio, where the SD molecules are embedded into the lipid bilayers, extends to about 10-1. Over this limit the separation of SD molecules can be observed at all investigated DPPE/DPPG ratios.
536 _ _ |0 G:(DE-Juel1)FUEK407
|2 G:(DE-HGF)
|a Terrestrische Umwelt
|c P24
|x 0
588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Bacteria: chemistry
650 _ 2 |2 MeSH
|a Cell Membrane: chemistry
650 _ 2 |2 MeSH
|a Lipid Bilayers: chemistry
650 _ 2 |2 MeSH
|a Molecular Structure
650 _ 2 |2 MeSH
|a Particle Size
650 _ 2 |2 MeSH
|a Phosphatidylethanolamines: chemistry
650 _ 2 |2 MeSH
|a Phosphatidylglycerols: chemistry
650 _ 2 |2 MeSH
|a Sulfadiazine: chemistry
650 _ 2 |2 MeSH
|a Surface Properties
650 _ 2 |2 MeSH
|a Temperature
650 _ 2 |2 MeSH
|a Water: chemistry
650 _ 7 |0 0
|2 NLM Chemicals
|a Lipid Bilayers
650 _ 7 |0 0
|2 NLM Chemicals
|a Phosphatidylethanolamines
650 _ 7 |0 0
|2 NLM Chemicals
|a Phosphatidylglycerols
650 _ 7 |0 3026-45-7
|2 NLM Chemicals
|a 1,2-dipalmitoyl-3-phosphatidylethanolamine
650 _ 7 |0 4537-77-3
|2 NLM Chemicals
|a 1,2-dipalmitoylphosphatidylglycerol
650 _ 7 |0 68-35-9
|2 NLM Chemicals
|a Sulfadiazine
650 _ 7 |0 7732-18-5
|2 NLM Chemicals
|a Water
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a Sulfadiazine
653 2 0 |2 Author
|a DPPE/DPPG vesicles
653 2 0 |2 Author
|a Phase separation
653 2 0 |2 Author
|a Unbinding
653 2 0 |2 Author
|a DSC
653 2 0 |2 Author
|a Small- and wide-angle X-ray scattering (SWAXS)
653 2 0 |2 Author
|a Freeze-fracture
700 1 _ |0 P:(DE-HGF)0
|a Bóta, A.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Berényi, S.
|b 2
700 1 _ |0 P:(DE-Juel1)129484
|a Klumpp, E.
|b 3
|u FZJ
773 _ _ |0 PERI:(DE-600)1500523-9
|a 10.1016/j.colsurfb.2009.12.013
|g Vol. 76, p. 519 - 528
|p 519 - 528
|q 76<519 - 528
|t Colloids and surfaces / B
|v 76
|x 0927-7765
|y 2010
909 C O |o oai:juser.fz-juelich.de:11681
|p VDB
913 1 _ |0 G:(DE-Juel1)FUEK407
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914 1 _ |y 2010
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |0 I:(DE-Juel1)VDB793
|d 31.10.2010
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970 _ _ |a VDB:(DE-Juel1)122971
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980 _ _ |a ConvertedRecord
980 _ _ |a journal
980 _ _ |a I:(DE-Juel1)IBG-3-20101118
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBG-3-20101118

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