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000011987 0247_ $$2DOI$$a10.1021/ac102256q
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000011987 084__ $$2WoS$$aChemistry, Analytical
000011987 1001_ $$0P:(DE-Juel1)VDB2662$$aBecker, J. S.$$b0$$uFZJ
000011987 245__ $$aBioimaging of Metals and Biomolecules in Mouse Heart by Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Secondary Ion Mass Spectrometry
000011987 260__ $$aColumbus, Ohio$$bAmerican Chemical Society$$c2010
000011987 300__ $$a9528 - 9533
000011987 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000011987 440_0 $$0364$$aAnalytical Chemistry$$v82$$x0003-2700$$y22
000011987 500__ $$aRecord converted from VDB: 12.11.2012
000011987 520__ $$aBioimaging mass spectrometric techniques allow direct mapping of metal and biomolecule distributions with high spatial resolution in biological tissue. In this study laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) was used for imaging of transition metals (Fe, Cu, Zn, Mn, and Ti), alkali and alkaline-earth metals (Na, K, Mg, and Ca, respectively), and selected nonmetals (such as C, P, and S) in native cryosections of mouse heart. The metal and nonmetal images clearly illustrated the shape and the anatomy of the samples. Zinc and copper were inhomogeneously distributed with average concentrations of 26 and 11 μg g(-1), respectively. Titanium and manganese were detected at concentrations reaching 1 and 2 μg g(-1), respectively. The highest regional metal concentration of 360 μg g(-1)was observed for iron in blood present in the lumen of the aorta. Secondary ion mass spectrometry (SIMS) as an elemental and biomolecular mass spectrometric technique was employed for imaging of Na, K, and selected biomolecules (e.g., phosphocholine, choline, cholesterol) in adjacent sections. Here, two different bioimaging techniques, LA-ICPMS and SIMS, were combined for the first time, yielding novel information on both elemental and biomolecular distributions.
000011987 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000011987 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000011987 588__ $$aDataset connected to Web of Science, Pubmed
000011987 650_2 $$2MeSH$$aAnimals
000011987 650_2 $$2MeSH$$aBismuth: chemistry
000011987 650_2 $$2MeSH$$aFeasibility Studies
000011987 650_2 $$2MeSH$$aLasers
000011987 650_2 $$2MeSH$$aMale
000011987 650_2 $$2MeSH$$aMass Spectrometry: methods
000011987 650_2 $$2MeSH$$aMetals: metabolism
000011987 650_2 $$2MeSH$$aMice
000011987 650_2 $$2MeSH$$aMolecular Imaging: methods
000011987 650_2 $$2MeSH$$aMyocardium: metabolism
000011987 650_7 $$00$$2NLM Chemicals$$aMetals
000011987 650_7 $$07440-69-9$$2NLM Chemicals$$aBismuth
000011987 650_7 $$2WoSType$$aJ
000011987 7001_ $$0P:(DE-Juel1)VDB2782$$aBreuer, U.$$b1$$uFZJ
000011987 7001_ $$0P:(DE-Juel1)VDB93002$$aHsieh, H.-F.$$b2$$uFZJ
000011987 7001_ $$0P:(DE-Juel1)VDB95269$$aOsterholt, T.$$b3$$uFZJ
000011987 7001_ $$0P:(DE-Juel1)VDB92998$$aKumtabtim, U.$$b4$$uFZJ
000011987 7001_ $$0P:(DE-Juel1)138881$$aWu, B.$$b5$$uFZJ
000011987 7001_ $$0P:(DE-Juel1)138474$$aMatusch, A.$$b6$$uFZJ
000011987 7001_ $$0P:(DE-HGF)0$$aCaruso, J.A.$$b7
000011987 7001_ $$0P:(DE-HGF)0$$aQin, Z.$$b8
000011987 773__ $$0PERI:(DE-600)1483443-1$$a10.1021/ac102256q$$gVol. 82, p. 9528 - 9533$$p9528 - 9533$$q82<9528 - 9533$$tAnalytical chemistry$$v82$$x0003-2700$$y2010
000011987 8567_ $$uhttp://dx.doi.org/10.1021/ac102256q
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