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@ARTICLE{Becker:11987,
      author       = {Becker, J. S. and Breuer, U. and Hsieh, H.-F. and
                      Osterholt, T. and Kumtabtim, U. and Wu, B. and Matusch, A.
                      and Caruso, J.A. and Qin, Z.},
      title        = {{B}ioimaging of {M}etals and {B}iomolecules in {M}ouse
                      {H}eart by {L}aser {A}blation {I}nductively {C}oupled
                      {P}lasma {M}ass {S}pectrometry and {S}econdary {I}on {M}ass
                      {S}pectrometry},
      journal      = {Analytical chemistry},
      volume       = {82},
      issn         = {0003-2700},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {PreJuSER-11987},
      pages        = {9528 - 9533},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Bioimaging mass spectrometric techniques allow direct
                      mapping of metal and biomolecule distributions with high
                      spatial resolution in biological tissue. In this study laser
                      ablation inductively coupled plasma mass spectrometry
                      (LA-ICPMS) was used for imaging of transition metals (Fe,
                      Cu, Zn, Mn, and Ti), alkali and alkaline-earth metals (Na,
                      K, Mg, and Ca, respectively), and selected nonmetals (such
                      as C, P, and S) in native cryosections of mouse heart. The
                      metal and nonmetal images clearly illustrated the shape and
                      the anatomy of the samples. Zinc and copper were
                      inhomogeneously distributed with average concentrations of
                      26 and 11 μg g(-1), respectively. Titanium and manganese
                      were detected at concentrations reaching 1 and 2 μg g(-1),
                      respectively. The highest regional metal concentration of
                      360 μg g(-1)was observed for iron in blood present in the
                      lumen of the aorta. Secondary ion mass spectrometry (SIMS)
                      as an elemental and biomolecular mass spectrometric
                      technique was employed for imaging of Na, K, and selected
                      biomolecules (e.g., phosphocholine, choline, cholesterol) in
                      adjacent sections. Here, two different bioimaging
                      techniques, LA-ICPMS and SIMS, were combined for the first
                      time, yielding novel information on both elemental and
                      biomolecular distributions.},
      keywords     = {Animals / Bismuth: chemistry / Feasibility Studies / Lasers
                      / Male / Mass Spectrometry: methods / Metals: metabolism /
                      Mice / Molecular Imaging: methods / Myocardium: metabolism /
                      Metals (NLM Chemicals) / Bismuth (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ZCH / INM-1 / INM-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Chemistry, Analytical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20977196},
      UT           = {WOS:000284080500056},
      doi          = {10.1021/ac102256q},
      url          = {https://juser.fz-juelich.de/record/11987},
}