000012042 001__ 12042
000012042 005__ 20180208223055.0
000012042 0247_ $$2pmid$$apmid:15540119
000012042 0247_ $$2DOI$$a10.1007/s10342-010-0410-3
000012042 0247_ $$2WOS$$aWOS:000283155900021
000012042 037__ $$aPreJuSER-12042
000012042 041__ $$aeng
000012042 082__ $$a630
000012042 084__ $$2WoS$$aForestry
000012042 1001_ $$0P:(DE-HGF)0$$aJonard, M.$$b0
000012042 245__ $$aThirteen-year monitoring of liming and PK fertilization effects on tree vitality in Norway spruce and European beech stands
000012042 260__ $$aBerlin$$bSpringer$$c2010
000012042 300__ $$a1203 - 1211
000012042 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000012042 3367_ $$2DataCite$$aOutput Types/Journal article
000012042 3367_ $$00$$2EndNote$$aJournal Article
000012042 3367_ $$2BibTeX$$aARTICLE
000012042 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000012042 3367_ $$2DRIVER$$aarticle
000012042 440_0 $$014101$$aEuropean Journal of Forest Research$$v129$$x1612-4669
000012042 500__ $$aThis study was conducted with the support of the European Commission (regulation 3528) and of the Walloon Region (DGARNE/DNF) through the framework programs on forest research 1999-2004 and 2004-2009. We would like to thank Frederic Hardy and Francois Plume for their technical help, Francois Herman for the management of the database and Karine Henin for carrying out the chemical analyses.
000012042 520__ $$aLiposarcomas are a phenotypical heterogeneous group of tumors divided into four main subtypes: well-differentiated, dedifferentiated, myxoid/round cell, and pleomorphic. The aim of this study was to compare DNA sequence copy number changes of these subtypes as investigated by comparative genomic hybridization in 36 patients. Comparative genomic hybridization revealed genomic imbalances in tumors of 27 patients (mean 5.6 imbalances per tumor). The most frequent gains were within single regions of 1q, 12q, and 13q. We found a significant correlation of poor overall survival and gain of 13q21 (P=0.0221), 13q22 (P=0.0341), 13q31 (P=0.0410), and 13q32 (P=0.0074). The univariate Cox regression analysis revealed an increased risk of tumor-related death for patients whose liposarcomas possess with gains of 13q21 and 13q32 simultaneously (P=0.010; RR=7.1; 95% CI 1.6-31.7). Furthermore, 12 high-level amplifications were found in tumors of seven patients. In four cases 12q14-q15 and in two cases 13q32-q33 were amplified. We identified in different liposarcoma subtypes characteristic genomic changes: Gains and high-level amplifications of 12q occurred in all 11 investigated well-differentiated liposarcomas, and these changes were often present simultaneously with gains of 1q (mean 5.5 changes). In the two dedifferentiated liposarcomas, gains of 1q in both liposarcomas, and a high-level amplification of 13q were striking. Only eight of the 17 patients with myxoid/round cell liposarcomas showed changes in DNA copy number (mean 3.4 imbalances). In four of these eight cases gains of 13q occurred. The six pleomorphic liposarcomas possessed the most frequent genomic imbalances (mean number 16.3) of all liposarcoma subtypes investigated. These imbalances were in almost all chromosomal regions detected predominantly as over-representations of chromosomes 1, 5p, 13q, and 22q. Summarizing, all subtypes but well-differentiated liposarcomas showed gains of 13q, which were associated with a poor prognosis.
000012042 536__ $$0G:(DE-Juel1)FUEK407$$2G:(DE-HGF)$$aTerrestrische Umwelt$$cP24$$x0
000012042 588__ $$aDataset connected to Web of Science, Pubmed
000012042 650_2 $$2MeSH$$aAdult
000012042 650_2 $$2MeSH$$aAged
000012042 650_2 $$2MeSH$$aChromosome Aberrations
000012042 650_2 $$2MeSH$$aChromosomes, Human, Pair 1: genetics
000012042 650_2 $$2MeSH$$aChromosomes, Human, Pair 12: genetics
000012042 650_2 $$2MeSH$$aChromosomes, Human, Pair 13: genetics
000012042 650_2 $$2MeSH$$aFemale
000012042 650_2 $$2MeSH$$aHumans
000012042 650_2 $$2MeSH$$aLiposarcoma: genetics
000012042 650_2 $$2MeSH$$aLiposarcoma: pathology
000012042 650_2 $$2MeSH$$aMale
000012042 650_2 $$2MeSH$$aMiddle Aged
000012042 650_2 $$2MeSH$$aNucleic Acid Hybridization: methods
000012042 650_2 $$2MeSH$$aPrognosis
000012042 650_2 $$2MeSH$$aSurvival Analysis
000012042 650_7 $$2WoSType$$aJ
000012042 65320 $$2Author$$aLiming
000012042 65320 $$2Author$$aFertilization
000012042 65320 $$2Author$$aFoliar chemistry
000012042 65320 $$2Author$$aCrown condition
000012042 65320 $$2Author$$aTree growth
000012042 7001_ $$0P:(DE-Juel1)VDB85547$$aAndré, F.$$b1$$uFZJ
000012042 7001_ $$0P:(DE-HGF)0$$aGiot, P.$$b2
000012042 7001_ $$0P:(DE-HGF)0$$aWeissen, F.$$b3
000012042 7001_ $$0P:(DE-HGF)0$$aVan der Perre, R.$$b4
000012042 7001_ $$0P:(DE-HGF)0$$aPonette, Q.$$b5
000012042 773__ $$0PERI:(DE-600)2134019-5$$a10.1007/s10342-010-0410-3$$gVol. 129, p. 1203 - 1211$$p1203 - 1211$$q129<1203 - 1211$$tEuropean journal of forest research$$v129$$x1612-4669$$y2010
000012042 8567_ $$uhttp://dx.doi.org/10.1007/s10342-010-0410-3
000012042 909CO $$ooai:juser.fz-juelich.de:12042$$pVDB
000012042 9131_ $$0G:(DE-Juel1)FUEK407$$bErde und Umwelt$$kP24$$lTerrestrische Umwelt$$vTerrestrische Umwelt$$x0
000012042 9141_ $$y2010
000012042 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000012042 9201_ $$0I:(DE-Juel1)VDB793$$d31.10.2010$$gICG$$kICG-4$$lAgrosphäre$$x1
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