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@ARTICLE{Jonard:12042,
      author       = {Jonard, M. and André, F. and Giot, P. and Weissen, F. and
                      Van der Perre, R. and Ponette, Q.},
      title        = {{T}hirteen-year monitoring of liming and {PK} fertilization
                      effects on tree vitality in {N}orway spruce and {E}uropean
                      beech stands},
      journal      = {European journal of forest research},
      volume       = {129},
      issn         = {1612-4669},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-12042},
      pages        = {1203 - 1211},
      year         = {2010},
      note         = {This study was conducted with the support of the European
                      Commission (regulation 3528) and of the Walloon Region
                      (DGARNE/DNF) through the framework programs on forest
                      research 1999-2004 and 2004-2009. We would like to thank
                      Frederic Hardy and Francois Plume for their technical help,
                      Francois Herman for the management of the database and
                      Karine Henin for carrying out the chemical analyses.},
      abstract     = {Liposarcomas are a phenotypical heterogeneous group of
                      tumors divided into four main subtypes: well-differentiated,
                      dedifferentiated, myxoid/round cell, and pleomorphic. The
                      aim of this study was to compare DNA sequence copy number
                      changes of these subtypes as investigated by comparative
                      genomic hybridization in 36 patients. Comparative genomic
                      hybridization revealed genomic imbalances in tumors of 27
                      patients (mean 5.6 imbalances per tumor). The most frequent
                      gains were within single regions of 1q, 12q, and 13q. We
                      found a significant correlation of poor overall survival and
                      gain of 13q21 (P=0.0221), 13q22 (P=0.0341), 13q31
                      (P=0.0410), and 13q32 (P=0.0074). The univariate Cox
                      regression analysis revealed an increased risk of
                      tumor-related death for patients whose liposarcomas possess
                      with gains of 13q21 and 13q32 simultaneously (P=0.010;
                      RR=7.1; $95\%$ CI 1.6-31.7). Furthermore, 12 high-level
                      amplifications were found in tumors of seven patients. In
                      four cases 12q14-q15 and in two cases 13q32-q33 were
                      amplified. We identified in different liposarcoma subtypes
                      characteristic genomic changes: Gains and high-level
                      amplifications of 12q occurred in all 11 investigated
                      well-differentiated liposarcomas, and these changes were
                      often present simultaneously with gains of 1q (mean 5.5
                      changes). In the two dedifferentiated liposarcomas, gains of
                      1q in both liposarcomas, and a high-level amplification of
                      13q were striking. Only eight of the 17 patients with
                      myxoid/round cell liposarcomas showed changes in DNA copy
                      number (mean 3.4 imbalances). In four of these eight cases
                      gains of 13q occurred. The six pleomorphic liposarcomas
                      possessed the most frequent genomic imbalances (mean number
                      16.3) of all liposarcoma subtypes investigated. These
                      imbalances were in almost all chromosomal regions detected
                      predominantly as over-representations of chromosomes 1, 5p,
                      13q, and 22q. Summarizing, all subtypes but
                      well-differentiated liposarcomas showed gains of 13q, which
                      were associated with a poor prognosis.},
      keywords     = {Adult / Aged / Chromosome Aberrations / Chromosomes, Human,
                      Pair 1: genetics / Chromosomes, Human, Pair 12: genetics /
                      Chromosomes, Human, Pair 13: genetics / Female / Humans /
                      Liposarcoma: genetics / Liposarcoma: pathology / Male /
                      Middle Aged / Nucleic Acid Hybridization: methods /
                      Prognosis / Survival Analysis / J (WoSType)},
      cin          = {ICG-4},
      ddc          = {630},
      cid          = {I:(DE-Juel1)VDB793},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Forestry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:15540119},
      UT           = {WOS:000283155900021},
      doi          = {10.1007/s10342-010-0410-3},
      url          = {https://juser.fz-juelich.de/record/12042},
}