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@ARTICLE{Armstrong:12054,
      author       = {Armstrong, C.L. and Kaye, M.D. and Zamponi, M. and
                      Mamontov, E. and Tyagi, M. and Jenkins, T. and
                      Rheinstädter, M.C.},
      title        = {{D}iffusion in single supported lipid bilayers studied by
                      quasi-elastic neutron scattering},
      journal      = {Soft matter},
      volume       = {6},
      issn         = {1744-683X},
      address      = {Cambridge},
      publisher    = {Royal Society of Chemistry (RSC)},
      reportid     = {PreJuSER-12054},
      pages        = {5864 - 5867},
      year         = {2010},
      note         = {This research was supported by the Natural Sciences and
                      Engineering Research Council of Canada (NSERC), the National
                      Research Council Canada (NRC) and the Canada Foundation for
                      Innovation (CFI). This work utilized facilities at the NIST
                      Center for Neutron Research supported in part by the NSF
                      under agreement No. DMR-0454672. Research at Oak Ridge
                      National Laboratory's Spallation Neutron Source was
                      sponsored by the Scientific User Facilities Division, Office
                      of Basic Energy Sciences, U. S. Department of Energy.},
      abstract     = {It seems to be increasingly accepted that the diversity and
                      composition of lipids play an important role in the function
                      of biological membranes. A prime example of this is the case
                      of lipid rafts; regions enriched with certain types of
                      lipids which are speculated to be relevant to the proper
                      functioning of membrane embedded proteins. Although the
                      dynamics of membrane systems have been studied for decades,
                      the microscopic dynamics of lipid molecules, even in simple
                      model systems, is still an active topic of debate. Neutron
                      scattering has proven to be an important tool for accessing
                      the relevant nanometre length scale and nano to picosecond
                      time scales, thus providing complimentary information to
                      macroscopic techniques. Despite their potential relevance
                      for the development of functionalized surfaces and
                      biosensors, the study of single supported membranes using
                      neutron scattering poses the challenge of obtaining relevant
                      dynamic information from a sample with minimal material.
                      Using state of the art neutron instrumentation we were, for
                      the first time, able to model lipid diffusion in single
                      supported lipid bilayers. We find that the diffusion
                      coefficient for the single bilayer system is comparable to
                      the multi-lamellar lipid system. More importantly, the
                      molecular mechanism for lipid motion in the single bilayer
                      was found to be a continuous diffusion, rather than the
                      flow-like ballistic motion reported in the stacked membrane
                      system. We observed an enhanced diffusion at the nearest
                      neighbour distance of the lipid molecules. The enhancement
                      and change of character of the diffusion can most likely be
                      attributed to the effect the supporting substrate has on the
                      lipid organization.},
      keywords     = {J (WoSType)},
      cin          = {IFF-4 / IFF-5 / Jülich Centre for Neutron Science JCNS
                      (JCNS) ; JCNS},
      ddc          = {530},
      cid          = {I:(DE-Juel1)VDB784 / I:(DE-Juel1)VDB785 /
                      I:(DE-Juel1)JCNS-20121112},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung / Großgeräte für die Forschung
                      mit Photonen, Neutronen und Ionen (PNI)},
      pid          = {G:(DE-Juel1)FUEK505 / G:(DE-Juel1)FUEK415},
      shelfmark    = {Chemistry, Physical / Materials Science, Multidisciplinary
                      / Physics, Multidisciplinary / Polymer Science},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000284313700006},
      doi          = {10.1039/c0sm00637h},
      url          = {https://juser.fz-juelich.de/record/12054},
}