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000012506 0247_ $$2pmid$$apmid:20714607
000012506 0247_ $$2DOI$$a10.1039/C0CP01048K
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000012506 0247_ $$2ISSN$$a1463-9076
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000012506 041__ $$aeng
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000012506 084__ $$2WoS$$aChemistry, Physical
000012506 084__ $$2WoS$$aPhysics, Atomic, Molecular & Chemical
000012506 1001_ $$0P:(DE-HGF)0$$aJasnin, M.$$b0
000012506 245__ $$aSpecific cellular water dynamics observed in vivo by neutron scattering and NMR
000012506 260__ $$aCambridge$$bRSC Publ.$$c2010
000012506 300__ $$a10154 - 10160
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000012506 440_0 $$04916$$aPhysical Chemistry Chemical Physics$$v12$$x1463-9076$$y35
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000012506 520__ $$aNeutron scattering, by using deuterium labelling, revealed how intracellular water dynamics, measured in vivo in E. coli, human red blood cells and the extreme halophile, Haloarcula marismortui, depends on the cell type and nature of the cytoplasm. The method uniquely permits the determination of motions on the molecular length (approximately ångstrøm) and time (pico- to nanosecond) scales. In the bacterial and human cells, intracellular water beyond the hydration shells of cytoplasmic macromolecules and membrane faces flows as freely as liquid water. It is not "tamed" by confinement. In contrast, in the extreme halophile archaeon, in addition to free and hydration water an intracellular water component was observed with significantly slowed down translational diffusion. The results are discussed and compared to observations in E. coli and Haloarcula marismortui by deuteron spin relaxation in NMR--a method that is sensitive to water rotational dynamics on a wide range of time scales.
000012506 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x0
000012506 588__ $$aDataset connected to Web of Science, Pubmed
000012506 650_2 $$2MeSH$$aErythrocytes: metabolism
000012506 650_2 $$2MeSH$$aEscherichia coli: cytology
000012506 650_2 $$2MeSH$$aEscherichia coli: metabolism
000012506 650_2 $$2MeSH$$aHaloarcula marismortui: cytology
000012506 650_2 $$2MeSH$$aHaloarcula marismortui: metabolism
000012506 650_2 $$2MeSH$$aHemoglobins: metabolism
000012506 650_2 $$2MeSH$$aHumans
000012506 650_2 $$2MeSH$$aMagnetic Resonance Spectroscopy
000012506 650_2 $$2MeSH$$aNeutron Diffraction
000012506 650_2 $$2MeSH$$aWater: metabolism
000012506 650_7 $$00$$2NLM Chemicals$$aHemoglobins
000012506 650_7 $$07732-18-5$$2NLM Chemicals$$aWater
000012506 650_7 $$2WoSType$$aJ
000012506 7001_ $$0P:(DE-Juel1)VDB86542$$aStadler, A.$$b1$$uFZJ
000012506 7001_ $$0P:(DE-HGF)0$$aTehei, M$$b2
000012506 7001_ $$0P:(DE-HGF)0$$aZaccai, G.$$b3
000012506 773__ $$0PERI:(DE-600)1476244-4$$a10.1039/c0cp01048k$$gVol. 12, p. 10154 - 10160$$p10154 - 10160$$q12<10154 - 10160$$tPhysical Chemistry Chemical Physics$$v12$$x1463-9076$$y2010
000012506 8567_ $$uhttp://dx.doi.org/10.1039/C0CP01048K
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000012506 9131_ $$0G:(DE-Juel1)FUEK505$$bSchlüsseltechnologien$$kP45$$lBiologische Informationsverarbeitung$$vBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$x0
000012506 9132_ $$0G:(DE-HGF)POF3-552$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vEngineering Cell Function$$x0
000012506 9141_ $$y2010
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000012506 9201_ $$0I:(DE-Juel1)ISB-2-20090406$$d31.12.2010$$gISB$$kISB-2$$lMolekulare Biophysik$$x0
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