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@ARTICLE{Elmenhorst:127929,
      author       = {Elmenhorst, David and Kroll, Tina and Matusch, Andreas and
                      Bauer, Andreas},
      title        = {{S}leep {D}eprivation {I}ncreases {C}erebral {S}erotonin
                      2{A} {R}eceptor {B}inding in {H}umans},
      journal      = {Sleep},
      volume       = {35},
      number       = {12},
      address      = {Darien, Ill.},
      publisher    = {American Academy of Sleep Medicine and the Sleep Research
                      Society},
      reportid     = {FZJ-2012-00875},
      pages        = {1615-23},
      year         = {2012},
      abstract     = {STUDY OBJECTIVES: Serotonin and its cerebral receptors play
                      an important role in sleep-wake regulation. The aim of the
                      current study is to investigate the effect of 24-h total
                      sleep deprivation on the apparent serotonin 2A receptor
                      (5-HT(2A)R) binding capacity in the human brain to test the
                      hypothesis that sleep deprivation induces global molecular
                      alterations in the cortical serotonergic receptor system.
                      DESIGN: Volunteers were tested twice with the
                      subtype-selective radiotracer [(18)F]altanserin and positron
                      emission tomography (PET) for imaging of 5-HT(2A)Rs at
                      baseline and after 24 h of sleep deprivation.
                      [(18)F]Altanserin binding potentials were analyzed in 13
                      neocortical regions of interest. The efficacy of sleep
                      deprivation was assessed by questionnaires, waking
                      electroencephalography, and cognitive performance
                      measurements. SETTING: Sleep laboratory and neuroimaging
                      center. PATIENTS OR PARTICIPANTS: Eighteen healthy
                      volunteers. INTERVENTIONS: Sleep deprivation. MEASUREMENTS
                      AND RESULTS: A total of 24 hours of sleep deprivation led to
                      a $9.6\%$ increase of [(18)F]altanserin binding on
                      neocortical 5-HT(2A) receptors. Significant region-specific
                      increases were found in the medial inferior frontal gyrus,
                      insula, and anterior cingulate, parietal, sensomotoric, and
                      ventrolateral prefrontal cortices. CONCLUSIONS: This study
                      demonstrates that a single night of total sleep deprivation
                      causes significant increases of 5-HT(2A)R binding potentials
                      in a variety of cortical regions although the increase
                      declines as sleep deprivation continued. It provides in vivo
                      evidence that total sleep deprivation induces adaptive
                      processes in the serotonergic system of the human brain.
                      CITATION: Elmenhorst D; Kroll T; Matusch A; Bauer A. Sleep
                      Deprivation Increases Cerebral Serotonin 2A Receptor Binding
                      in Humans},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89571 - Connectivity and
                      Activity (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000313000600007},
      pubmed       = {pmid:23204604},
      doi          = {10.5665/sleep.2230},
      url          = {https://juser.fz-juelich.de/record/127929},
}