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000127931 1001_ $$0P:(DE-HGF)0$$aHellwig, Sabine$$b0
000127931 245__ $$aReelin Together with ApoER2 Regulates Interneuron Migration in the Olfactory Bulb
000127931 260__ $$aLawrence, Kan.$$bPLoS$$c2012
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000127931 520__ $$aOne pathway regulating the migration of neurons during development of the mammalian cortex involves the extracellular matrix protein Reelin. Reelin and components of its signaling cascade, the lipoprotein receptors ApoER2 and Vldlr and the intracellular adapter protein Dab1 are pivotal for a correct layer formation during corticogenesis. The olfactory bulb (OB) as a phylogenetically old cortical region is known to be a prominent site of Reelin expression. Although some aspects of Reelin function in the OB have been described, the influence of Reelin on OB layer formation has so far been poorly analyzed. Here we studied animals deficient for either Reelin, Vldlr, ApoER2 or Dab1 as well as double-null mutants. We performed organotypic migration assays, immunohistochemical marker analysis and BrdU incorporation studies to elucidate roles for the different components of the Reelin signaling cascade in OB neuroblast migration and layer formation. We identified ApoER2 as being the main receptor responsible for Reelin mediated detachment of neuroblasts and correct migration of early generated interneurons within the OB, a prerequisite for correct OB lamination
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000127931 7001_ $$0P:(DE-Juel1)141620$$aHack, Iris$$b1
000127931 7001_ $$0P:(DE-HGF)0$$aZucker, Birgit$$b2
000127931 7001_ $$0P:(DE-HGF)0$$aBrunne, Bianka$$b3
000127931 7001_ $$0P:(DE-HGF)0$$aJunghans, Dirk$$b4
000127931 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0050646$$n11$$pe50646 -$$tPLoS one$$v7$$y2012
000127931 8564_ $$yPublished under CreativeCommons License$$zPublished final document.
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000127931 9141_ $$y2012
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