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@ARTICLE{Hellwig:127931,
      author       = {Hellwig, Sabine and Hack, Iris and Zucker, Birgit and
                      Brunne, Bianka and Junghans, Dirk},
      title        = {{R}eelin {T}ogether with {A}po{ER}2 {R}egulates
                      {I}nterneuron {M}igration in the {O}lfactory {B}ulb},
      journal      = {PLoS one},
      volume       = {7},
      number       = {11},
      address      = {Lawrence, Kan.},
      publisher    = {PLoS},
      reportid     = {FZJ-2012-00877},
      pages        = {e50646 -},
      year         = {2012},
      abstract     = {One pathway regulating the migration of neurons during
                      development of the mammalian cortex involves the
                      extracellular matrix protein Reelin. Reelin and components
                      of its signaling cascade, the lipoprotein receptors ApoER2
                      and Vldlr and the intracellular adapter protein Dab1 are
                      pivotal for a correct layer formation during corticogenesis.
                      The olfactory bulb (OB) as a phylogenetically old cortical
                      region is known to be a prominent site of Reelin expression.
                      Although some aspects of Reelin function in the OB have been
                      described, the influence of Reelin on OB layer formation has
                      so far been poorly analyzed. Here we studied animals
                      deficient for either Reelin, Vldlr, ApoER2 or Dab1 as well
                      as double-null mutants. We performed organotypic migration
                      assays, immunohistochemical marker analysis and BrdU
                      incorporation studies to elucidate roles for the different
                      components of the Reelin signaling cascade in OB neuroblast
                      migration and layer formation. We identified ApoER2 as being
                      the main receptor responsible for Reelin mediated detachment
                      of neuroblasts and correct migration of early generated
                      interneurons within the OB, a prerequisite for correct OB
                      lamination},
      cin          = {INM-2},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {331 - Signalling Pathways and Mechanisms in the Nervous
                      System (POF2-331) / 89571 - Connectivity and Activity
                      (POF2-89571)},
      pid          = {G:(DE-HGF)POF2-331 / G:(DE-HGF)POF2-89571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000312104900073},
      doi          = {10.1371/journal.pone.0050646},
      url          = {https://juser.fz-juelich.de/record/127931},
}