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000128612 0247_ $$2doi$$a10.1088/0957-4484/23/49/495303
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000128612 1001_ $$aWesche, Manuel$$b0$$uFZJ
000128612 245__ $$aA nanoporous alumina microelectrode array for functional cell–chip coupling
000128612 260__ $$aBristol$$bIOP Publ.$$c2012
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000128612 520__ $$aThe design of electrode interfaces has a strong impact on cell-based bioelectronic applications. We present a new type of microelectrode array chip featuring a nanoporous alumina interface. The chip is fabricated in a combination of top-down and bottom-up processes using state-of-the-art clean room technology and self-assembled generation of nanopores by aluminum anodization. The electrode characteristics are investigated in phosphate buffered saline as well as under cell culture conditions. We show that the modified microelectrodes exhibit decreased impedance compared to planar microelectrodes, which is caused by a nanostructuring effect of the underlying gold during anodization. The stability and biocompatibility of the device are demonstrated by measuring action potentials from cardiomyocyte-like cells growing on top of the chip. Cross sections of the cell–surface interface reveal that the cell membrane seals the nanoporous alumina layer without bending into the sub-50 nm apertures. The nanoporous microelectrode array device may be used as a platform for combining extracellular recording of cell activity with stimulating topographical cues.
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000128612 7001_ $$0P:(DE-Juel1)128689$$aHüske, Martin$$b1
000128612 7001_ $$0P:(DE-Juel1)138367$$aYakushenko, Alexey$$b2
000128612 7001_ $$0P:(DE-HGF)0$$aBrüggemann, Dorothea$$b3
000128612 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b4
000128612 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b5
000128612 7001_ $$0P:(DE-Juel1)128745$$aWolfrum, Bernhard$$b6$$eCorresponding author
000128612 773__ $$0PERI:(DE-600)1362365-5$$a10.1088/0957-4484/23/49/495303$$gVol. 23, no. 49, p. 495303 -$$n49$$p495303 -$$tNanotechnology$$v23$$x1361-6528$$y2012
000128612 8564_ $$uhttp://iopscience.iop.org/0957-4484/23/49/495303
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