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@ARTICLE{Cheng:129147,
      author       = {Cheng, Ji and Zhu, Geng and Wu, Lei and Du, Xiaowei and
                      Zhang, Huanqian and Wolfrum, Bernhard and Jin, Qinghui and
                      Zhao, Jianlong and Offenhäusser, Andreas and Xu, Yuansen},
      title        = {{P}hotopatterning of self-assembled poly (ethylene) glycol
                      monolayer for neuronal network fabrication},
      journal      = {Journal of neuroscience methods},
      volume       = {213},
      number       = {2},
      issn         = {0165-0270},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2013-00667},
      pages        = {196 - 203},
      year         = {2013},
      abstract     = {The ability to culture individual neurons and direct their
                      connections on functional interfaces provides a platform for
                      investigating information processing in neuronal networks.
                      Numerous methods have been used to design ordered neuronal
                      networks on microelectrode arrays (MEAs) for neuronal
                      electrical activities recording. However, so far, no method
                      has been implemented, which simultaneously provides
                      high-resolution neuronal patterns and low-impedance
                      microelectrode. To achieve this goal, we employed a chemical
                      vapor-deposited, non-fouling poly (ethylene) glycol (PEG)
                      self-assembled monolayer to provide a cell repellant
                      background on the MEAs. Photolithography, together with
                      plasma etching of the PEG monolayer, was used to fabricate
                      different patterns on MEAs. No electrode performance
                      degradation was observed after the whole process.
                      Dissociated cortical neurons were cultured on the modified
                      MEAs, and the patterns were maintained for more than 3
                      weeks. Spontaneous and evoked neuronal activities were
                      recorded. All of the results demonstrate this surface
                      engineering strategy allows successful patterning of neurons
                      on MEAs, and is useful for future studies of information
                      processing in defined neuronal networks on a chip.},
      cin          = {JARA-FIT / PGI-8 / ICS-8},
      ddc          = {610},
      cid          = {$I:(DE-82)080009_20140620$ / I:(DE-Juel1)PGI-8-20110106 /
                      I:(DE-Juel1)ICS-8-20110106},
      pnm          = {453 - Physics of the Cell (POF2-453) / 423 - Sensorics and
                      bioinspired systems (POF2-423)},
      pid          = {G:(DE-HGF)POF2-453 / G:(DE-HGF)POF2-423},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000315557200005},
      pubmed       = {pmid:23291086},
      doi          = {10.1016/j.jneumeth.2012.12.020},
      url          = {https://juser.fz-juelich.de/record/129147},
}