TY  - JOUR
AU  - Friedel, Swetlana
AU  - Usadel, Björn
AU  - von Wirén, Nicolaus
AU  - Sreenivasulu, Nese
TI  - Reverse Engineering: A Key Component of Systems Biology to Unravel Global Abiotic Stress Cross-Talk
JO  - Frontiers in Plant Physiology
VL  - 3
IS  - 294
SN  - 1664-462X
CY  - Lausanne
PB  - Frontiers Media83580
M1  - FZJ-2013-01142
SP  - 1-16
PY  - 2012
AB  - Understanding the global abiotic stress response is an important stepping stone for the development of universal stress tolerance in plants in the era of climate change. Although co-occurrence of several stress factors (abiotic and biotic) in nature is found to be frequent, current attempts are poor to understand the complex physiological processes impacting plant growth under combinatory factors. In this review article, we discuss the recent advances of reverse engineering approaches that led to seminal discoveries of key candidate regulatory genes involved in cross-talk of abiotic stress responses and summarized the available tools of reverse engineering and its relevant application. Among the universally induced regulators involved in various abiotic stress responses, we highlight the importance of (i) abscisic acid (ABA) and jasmonic acid (JA) hormonal cross-talks and (ii) the central role of WRKY transcription factors (TF), potentially mediating both abiotic and biotic stress responses. Such interactome networks help not only to derive hypotheses but also play a vital role in identifying key regulatory targets and interconnected hormonal responses. To explore the full potential of gene network inference in the area of abiotic stress tolerance, we need to validate hypotheses by implementing time-dependent gene expression data from genetically engineered plants with modulated expression of target genes. We further propose to combine information on gene-by-gene interactions with data from physical interaction platforms such as protein–protein or TF-gene networks.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000208837900288
C6  - pmid:23293646
DO  - DOI:10.3389/fpls.2012.00294
UR  - https://juser.fz-juelich.de/record/131882
ER  -