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@ARTICLE{Geisler:132057,
      author       = {Geisler, Stefanie and Willuweit, Antje and Schroeter,
                      Michael and Zilles, Karl and Hamacher, Kurt and Galldiks,
                      Norbert and Shah, N. J. and Coenen, Heinrich Hubert and
                      Langen, Karl-Josef},
      title        = {{D}etection of remote neuronal reactions in the {T}halamus
                      and {H}ippocampus induced by rat glioma using the {PET}
                      tracer cis-4-[(18){F}]fluoro-{D}-proline.},
      journal      = {Journal of cerebral blood flow $\&$ metabolism},
      volume       = {33},
      issn         = {1559-7016},
      address      = {[s.l.]},
      publisher    = {Ovid},
      reportid     = {FZJ-2013-01296},
      pages        = {724–731},
      year         = {2013},
      abstract     = {After cerebral ischemia or trauma, secondary
                      neurodegeneration may occur in brain regions remote from the
                      lesion. Little is known about the capacity of cerebral
                      gliomas to induce secondary neurodegeneration. A previous
                      study showed that cis-4-[(18)F]fluoro-D-proline
                      (D-cis-[(18)F]FPro) detects secondary reactions of thalamic
                      nuclei after cortical infarction with high sensitivity. Here
                      we investigated the potential of D-cis-[(18)F]FPro to detect
                      neuronal reactions in remote brain areas in the F98 rat
                      glioma model using ex vivo autoradiography. Although the
                      tumor tissue of F98 gliomas showed no significant
                      D-cis-[(18)F]FPro uptake, we observed prominent tracer
                      uptake in 7 of 10 animals in the nuclei of the ipsilateral
                      thalamus, which varied with the specific connectivity with
                      the cortical areas affected by the tumor. In addition,
                      strong D-cis-[(18)F]FPro accumulation was noted in the
                      hippocampal area CA1 in two animals with ipsilateral F98
                      gliomas involving hippocampal subarea CA3 rostral to that
                      area. Furthermore, focal D-cis-[(18)F]FPro uptake was
                      present in the necrotic center of the tumors.
                      Cis-4-[(18)F]fluoro-D-proline uptake was accompanied by
                      microglial activation in the thalamus, in the hippocampus,
                      and in the necrotic center of the tumors. The data suggest
                      that brain tumors induce secondary neuronal reactions in
                      remote brain areas, which may be detected by positron
                      emission tomography (PET) using D-cis-[(18)F]FPro.Journal of
                      Cerebral Blood Flow $\&$ Metabolism advance online
                      publication, 6 February 2013; doi:10.1038/jcbfm.2013.8.},
      cin          = {INM-1 / INM-4 / INM-3 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23385199},
      UT           = {WOS:000318394400012},
      doi          = {10.1038/jcbfm.2013.8},
      url          = {https://juser.fz-juelich.de/record/132057},
}