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| 001 | 132206 | ||
| 005 | 20210129211352.0 | ||
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| 100 | 1 | _ | |a Clos, Mareike |0 P:(DE-Juel1)139096 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Aberrant connectivity of areas for decoding degraded speech in patients with auditory verbal hallucinations. |
| 260 | _ | _ | |a Berlin |c 2014 |b Springer |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1394185766_18051 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a Auditory verbal hallucinations (AVH) are a hallmark of psychotic experience. Various mechanisms including misattribution of inner speech and imbalance between bottom-up and top-down factors in auditory perception potentially due to aberrant connectivity between frontal and temporo-parietal areas have been suggested to underlie AVH. Experimental evidence for disturbed connectivity of networks sustaining auditory-verbal processing is, however, sparse. We compared functional resting-state connectivity in 49 psychotic patients with frequent AVH and 49 matched controls. The analysis was seeded from the left middle temporal gyrus (MTG), thalamus, angular gyrus (AG) and inferior frontal gyrus (IFG) as these regions are implicated in extracting meaning from impoverished speech-like sounds. Aberrant connectivity was found for all seeds. Decreased connectivity was observed between the left MTG and its right homotope, between the left AG and the surrounding inferior parietal cortex (IPC) and the left inferior temporal gyrus, between the left thalamus and the right cerebellum, as well as between the left IFG and left IPC, and dorsolateral and ventrolateral prefrontal cortex (DLPFC/VLPFC). Increased connectivity was observed between the left IFG and the supplementary motor area (SMA) and the left insula and between the left thalamus and the left fusiform gyrus/hippocampus. The predisposition to experience AVH might result from decoupling between the speech production system (IFG, insula and SMA) and the self-monitoring system (DLPFC, VLPFC, IPC) leading to misattribution of inner speech. Furthermore, decreased connectivity between nodes involved in speech processing (AG, MTG) and other regions implicated in auditory processing might reflect aberrant top-down influences in AVH. |
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| 700 | 1 | _ | |a Eickhoff, Simon |0 P:(DE-Juel1)131678 |b 4 |
| 773 | _ | _ | |a 10.1007/s00429-013-0519-5 |p 581-594 |n 2 |0 PERI:(DE-600)2303775-1 |t Brain structure & function |v 219 |y 2014 |x 1863-2661 |
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